GMB-475

CAT: 0013-GTR19166002-02Size: 2 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19166002-02Size:2 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

GMB-475 is a PROTAC-based degrader that recruits the VHL E3 ligase to ubiquitinate and eliminate the BCR-ABL1 oncoprotein, overcoming kinase inhibitor resistance. It is a research tool for investigating targeted protein degradation in models of chronic myeloid leukemia (CML), both in cellular and preclinical in vivo studies.

CAS Number

2490599-18-1

Product Name Alternative

PROTACs, GMB 475, GMB475, GMB-475, Inhibitor, inhibit, Apoptosis, Bcr-Abl1, Bcr-Abl, BcrAbl

Field of Research

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology

Purity

98.78% (May vary between batches)

Solubility

DMSO:245 mg/mL (284.25 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (5.8 mM)

Smiles

Cc1ncsc1-c1ccc (CNC (=O) [C@@H]2C[C@@H] (O) CN2C (=O) [C@@H] (NC (=O) COCCOc2ccc (cc2) -c2cc (Nc3ccc (OC (F) (F) F) cc3) ncn2) C (C) (C) C) cc1

Molecular Formula

C43H46F3N7O7S

Molecular Weight

861.93

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

(2S,4R)-1-((S)-3,3-dimethyl-2-(2-(2-(4-(6-((4-(trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)phenoxy)ethoxy)acetamido)butanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

CAS Number	2490599-18-1
PubChem CID	139600282
IUPAC Name	(2S,4R)-1-[(2S)-3,3-dimethyl-2-[[2-[2-[4-[6-[4-(trifluoromethoxy)anilino]pyrimidin-4-yl]phenoxy]ethoxy]acetyl]amino]butanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide
Molecular Formula	C43H46F3N7O7S
Molecular Weight	861.9
XLogP	6.9
Topological Polar Surface Area	205
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	15
Rotatable Bond Count	17
Heavy Atom Count	61
Formal Charge	0
Complexity	1410

SMILES

CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)COCCOC4=CC=C(C=C4)C5=CC(=NC=N5)NC6=CC=C(C=C6)OC(F)(F)F)O

InChI

InChI=1S/C43H46F3N7O7S/c1-26-38(61-25-50-26)29-7-5-27(6-8-29)21-47-40(56)35-19-31(54)22-53(35)41(57)39(42(2,3)4)52-37(55)23-58-17-18-59-32-13-9-28(10-14-32)34-20-36(49-24-48-34)51-30-11-15-33(16-12-30)60-43(44,45)46/h5-16,20,24-25,31,35,39,54H,17-19,21-23H2,1-4H3,(H,47,56)(H,52,55)(H,48,49,51)/t31-,35+,39-/m1/s1

InChIKey

ONDVWISBMHHLGZ-SBJIGXGQSA-N

Chemical Structure

2D Structure

CAS: 2490599-18-1

CID: 139600282

Formula: C43H46F3N7O7S

MW: 861.9

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	861.9
XLogP3	6.9
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	15
Rotatable Bond Count	17
Exact Mass	861.31315249
Monoisotopic Mass	861.31315249
Topological Polar Surface Area	205 Å²
Heavy Atom Count	61
Formal Charge	0
Complexity	1410
Isotope Atom Count	0
Defined Atom Stereocenter Count	3
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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GTR19129138-01	Recombinant Human Zinc finger protein 475 (ZN475)
GTR19132501-01	Recombinant Human Zinc finger protein 475 (ZN475)
GTR19126621-01	Recombinant Human Zinc finger protein 475 (ZN475)
GTR19132794-01	Recombinant Human Zinc finger protein 475 (ZN475)
GTR19130395-01	Recombinant Human Zinc finger protein 475 (ZN475), Biotinylated
GTR19127878-01	Recombinant Human Zinc finger protein 475 (ZN475), Biotinylated
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Alternative Products

Catalog	Name
T8488-01	GMB-475
7265/5	GMB 475
ARC0871	SNU-475
ADC-P-094	17-GMB-APA-GA
HY-W953768	CRBN ligand-475
T1182	SNU-475 Cells

GMB-475

Chemical Information

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