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Metformin

CAT: 0013-GTR19165658-06Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19165658-06Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Metformin (1,1-Dimethylbiguanide) is a blood-brain barrier permeable AMPK activator used in type 2 diabetes research. It improves glycemic control by enhancing insulin sensitivity and reducing intestinal glucose absorption. This compound is widely applied in metabolic disease studies, including in vitro mechanistic investigations and in vivo animal models.
CAS Number
657-24-9
Product Name Alternative
Diabetes, chain, AMPK, Autophagy, barrier, blood-brain, AMP-activated protein kinase, 1,1-Dimethylbiguanide, inhibit, liver, Mitophagy, mitochondrial, Mitochondrial Autophagy, Metformin, insulin, Inhibitor, sensitivity, respiratory, type
Field of Research
Cell Biology, Epigenetics & Chromatin, Pharmacology & Drug Discovery, Signal Transduction
Purity
98.00% (May vary between batches)
Solubility
H2O:100 mg/mL (774.23 mM) ; DMSO:49 mg/mL (379.37 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (15.48 mM)
Smiles
CN (C) C (=N) NC (N) =N
Molecular Formula
C4H11N5
Molecular Weight
129.16
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Metformin

Metformin is a member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1. It has a role as a geroprotector, a hypoglycemic agent, a xenobiotic and an environmental contaminant. It is functionally related to a biguanide. It is a conjugate base of a metformin(1+).

CAS Number657-24-9
PubChem CID4091
IUPAC Name3-(diaminomethylidene)-1,1-dimethylguanidine
Molecular FormulaC4H11N5
Molecular Weight129.16
XLogP-1.3
Topological Polar Surface Area91.5
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count1
Rotatable Bond Count2
Heavy Atom Count9
Formal Charge0
Complexity132
SMILES
CN(C)C(=N)N=C(N)N
InChI
InChI=1S/C4H11N5/c1-9(2)4(7)8-3(5)6/h1-2H3,(H5,5,6,7,8)
InChIKey
XZWYZXLIPXDOLR-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Metformin
CAS: 657-24-9
CID: 4091
Formula: C4H11N5
MW: 129.16
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight129.16
XLogP3-1.3
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count1
Rotatable Bond Count2
Exact Mass129.10144537
Monoisotopic Mass129.10144537
Topological Polar Surface Area91.5 Ų
Heavy Atom Count9
Formal Charge0
Complexity132
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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