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NCGC 607

CAT: 0804-HY-120034-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-120034-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NCGC 607 is a noninhibitory small-molecule chaperone of glucocerebrosidase (GCase) . NCGC 607 can increase GCase activity, reduce α-synuclein levels, and decrease glycolipid levels. NCGC 607 can be used in the research of Gaucher disease and Parkinson's disease[1].
CAS Number
1462267-07-7
UNSPSC
12352005
Target
Glycosidase; α-synuclein
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ncgc-607.html
Purity
99.53
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
O=C(NCC(N(C)C1=CC=CC=C1)=O)C2=CC=CC=C2OCC(NC3=CC=C(I)C=C3)=O
Molecular Formula
C24H22IN3O4
Molecular Weight
543.35
References & Citations
[1]Aflaki E, et al. A New Glucocerebrosidase Chaperone Reduces α-Synuclein and Glycolipid Levels in iPSC-Derived Dopaminergic Neurons from Patients with Gaucher Disease and Parkinsonism. J Neurosci. 2016 Jul 13;36 (28) :7441-52.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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