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MRT-14

CAT: 0013-GTR19164749-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19164749-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MRT-14 is a potent and selective antagonist of Smoothened (Smo), effectively inhibiting the Hedgehog (Hh) signaling pathway. It is a valuable research tool for studying Hh-driven cancers, suitable for both in vitro cellular assays and in vivo preclinical models of malignancies such as medulloblastoma and basal cell carcinoma.
CAS Number
1263131-83-4
Product Name Alternative
Cancer, Hedgehog, inhibit, Inhibitor, MRT 14, MRT14, MRT-14, Smoothened, Smo
Field of Research
Stem Cell & Developmental Biology
Purity
98.55% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.46 mM) ; DMSO:50 mg/mL (111.49 mM)
Smiles
COc1cc (cc (OC) c1OC) C (=O) NC (=N) Nc1cccc (NC (=O) c2ccccc2) c1
Molecular Formula
C24H24N4O5
Molecular Weight
448.47
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

N-(N-(3-Benzamidophenyl)carbamimidoyl)-3,4,5-trimethoxybenzamide
CAS Number1263131-83-4
PubChem CID136210502
IUPAC NameN-[N'-(3-benzamidophenyl)carbamimidoyl]-3,4,5-trimethoxybenzamide
Molecular FormulaC24H24N4O5
Molecular Weight448.5
XLogP3.5
Topological Polar Surface Area124
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count8
Heavy Atom Count33
Formal Charge0
Complexity668
SMILES
COC1=CC(=CC(=C1OC)OC)C(=O)NC(=NC2=CC=CC(=C2)NC(=O)C3=CC=CC=C3)N
InChI
InChI=1S/C24H24N4O5/c1-31-19-12-16(13-20(32-2)21(19)33-3)23(30)28-24(25)27-18-11-7-10-17(14-18)26-22(29)15-8-5-4-6-9-15/h4-14H,1-3H3,(H,26,29)(H3,25,27,28,30)
InChIKey
CIWMWTKJZQOXBC-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-(N-(3-Benzamidophenyl)carbamimidoyl)-3,4,5-trimethoxybenzamide
CAS: 1263131-83-4
CID: 136210502
Formula: C24H24N4O5
MW: 448.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight448.5
XLogP33.5
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count8
Exact Mass448.17466988
Monoisotopic Mass448.17466988
Topological Polar Surface Area124 Ų
Heavy Atom Count33
Formal Charge0
Complexity668
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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