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Cycloleucine

CAT: 0013-GTR19164679-05Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19164679-05Size:1 g
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Description
Cycloleucine is a competitive antagonist of the glycine site on the NMDA receptor (Ki = 600 μM) and an inhibitor of S-adenosyl-methionine-dependent methylation. Its cytostatic and anxiolytic-like properties make it a useful research tool for studying neurotransmission, epigenetics, and cancer biology in both cellular and animal models.
CAS Number
52-52-8
Product Name Alternative
Cycloleucine, cytostatic, ATP, anxiolytic, iGluR, Inhibitor, glycine, inhibit, Ionotropic glutamate receptors, methylations, NMDA receptor, NMDA, nucleic, transferase
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purity
98.13% (May vary between batches)
Solubility
H2O:51.5 mg/mL (398.73 mM) ; DMSO:< 1 mg/mL (insoluble or slightly soluble)
Smiles
NC1 (CCCC1) C (O) =O
Molecular Formula
C6H11NO2
Molecular Weight
129.16
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Cycloleucine

1-aminocyclopentanecarboxylic acid is a non-proteinogenic alpha-amino acid that is cyclopentane substituted at position 1 by amino and carboxy groups. It has a role as an EC 2.5.1.6 (methionine adenosyltransferase) inhibitor.

CAS Number52-52-8
PubChem CID2901
IUPAC Name1-aminocyclopentane-1-carboxylic acid
Molecular FormulaC6H11NO2
Molecular Weight129.16
XLogP-2.6
Topological Polar Surface Area63.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Heavy Atom Count9
Formal Charge0
Complexity127
SMILES
C1CCC(C1)(C(=O)O)N
InChI
InChI=1S/C6H11NO2/c7-6(5(8)9)3-1-2-4-6/h1-4,7H2,(H,8,9)
InChIKey
NILQLFBWTXNUOE-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Cycloleucine
CAS: 52-52-8
CID: 2901
Formula: C6H11NO2
MW: 129.16
Interactive 3D Structure
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View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight129.16
XLogP3-2.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Exact Mass129.078978594
Monoisotopic Mass129.078978594
Topological Polar Surface Area63.3 Ų
Heavy Atom Count9
Formal Charge0
Complexity127
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS3617325-01Cycloleucine
265328-01Boc-cycloleucine
C32057-01Cycloleucine 97%
TYD-03196-01Cycloleucine-CoA
450447-01Fmoc-Cycloleucine

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