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Ko 143

CAT: 0013-GTR19164545-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19164545-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ko 143 is a potent and selective small molecule inhibitor of the ABCG2/BCRP transporter. This compound is widely used in pharmacological research to study drug efflux, bioavailability, and multidrug resistance in both cellular and animal models.
CAS Number
461054-93-3
Product Name Alternative
Breast cancer resistance protein, BCRP, ABCG2, Ko 143, Ko143, Ko-143, inhibit, Inhibitor
Field of Research
Pharmacology & Drug Discovery
Purity
98.91% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.03 mM) ; DMSO:90 mg/mL (191.66 mM) ; H2O:Insoluble
Smiles
COc1ccc2c3C[C@@H]4N ([C@@H] (CC (C) C) c3[nH]c2c1) C (=O) [C@H] (CCC (=O) OC (C) (C) C) NC4=O
Molecular Formula
C26H35N3O5
Molecular Weight
469.57
Storage Conditions
Store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Notes
For research use only.

Chemical Information

Ko 143

LSM-6260 is a tert-butyl ester and a member of beta-carbolines.

CAS Number461054-93-3
PubChem CID10322450
IUPAC Nametert-butyl 3-[(2S,5S,8S)-14-methoxy-2-(2-methylpropyl)-4,7-dioxo-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraen-5-yl]propanoate
Molecular FormulaC26H35N3O5
Molecular Weight469.6
XLogP3.5
Topological Polar Surface Area101
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count8
Heavy Atom Count34
Formal Charge0
Complexity794
SMILES
CC(C)C[C@H]1C2=C(C[C@@H]3N1C(=O)[C@@H](NC3=O)CCC(=O)OC(C)(C)C)C4=C(N2)C=C(C=C4)OC
InChI
InChI=1S/C26H35N3O5/c1-14(2)11-20-23-17(16-8-7-15(33-6)12-19(16)27-23)13-21-24(31)28-18(25(32)29(20)21)9-10-22(30)34-26(3,4)5/h7-8,12,14,18,20-21,27H,9-11,13H2,1-6H3,(H,28,31)/t18-,20-,21-/m0/s1
InChIKey
NXNRAECHCJZNRF-JBACZVJFSA-N
Chemical Structure
2D Structure
2D structure of Ko 143
CAS: 461054-93-3
CID: 10322450
Formula: C26H35N3O5
MW: 469.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight469.6
XLogP33.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count8
Exact Mass469.25767123
Monoisotopic Mass469.25767123
Topological Polar Surface Area101 Ų
Heavy Atom Count34
Formal Charge0
Complexity794
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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