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UNC0646

CAT: 0013-GTR19164508-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19164508-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
UNC0646 is a potent, selective dual inhibitor of the histone methyltransferases G9a and GLP, demonstrating nanomolar cellular activity and low cytotoxicity. It is a valuable chemical probe for epigenetic research, widely used in vitro and in vivo to study histone methylation's role in cancer, neurology, and development.
CAS Number
1320288-17-2
Product Name Alternative
SAR, PKMT, UNC 0646, UNC0646, UNC-0646, p53, KMT1D, inhibit, HistoneMethyltransferase, Histone Methyltransferase, Inhibitor, H3K9me2, G9a, GLP, EHMT1, cell-penetration, chromatin
Field of Research
Epigenetics & Chromatin
Purity
99.59% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (6.43 mM) ; DMSO:30 mg/mL (48.24 mM)
Smiles
COc1cc2c (NC3CCN (CC3) C3CCCCC3) nc (nc2cc1OCCCN1CCCCC1) N1CCCN (CC1) C (C) C
Molecular Formula
C36H59N7O2
Molecular Weight
621.9
Storage Conditions
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Notes
For research use only.

Chemical Information

Unc-0646

N-(1-cyclohexyl-4-piperidinyl)-6-methoxy-7-[3-(1-piperidinyl)propoxy]-2-(4-propan-2-yl-1,4-diazepan-1-yl)-4-quinazolinamine is a member of quinazolines.

CAS Number1320288-17-2
PubChem CID53315882
IUPAC NameN-(1-cyclohexylpiperidin-4-yl)-6-methoxy-7-(3-piperidin-1-ylpropoxy)-2-(4-propan-2-yl-1,4-diazepan-1-yl)quinazolin-4-amine
Molecular FormulaC36H59N7O2
Molecular Weight621.9
XLogP6.9
Topological Polar Surface Area69.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count11
Heavy Atom Count45
Formal Charge0
Complexity845
SMILES
CC(C)N1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)NC4CCN(CC4)C5CCCCC5)OC)OCCCN6CCCCC6
InChI
InChI=1S/C36H59N7O2/c1-28(2)41-19-10-20-43(24-23-41)36-38-32-27-34(45-25-11-18-40-16-8-5-9-17-40)33(44-3)26-31(32)35(39-36)37-29-14-21-42(22-15-29)30-12-6-4-7-13-30/h26-30H,4-25H2,1-3H3,(H,37,38,39)
InChIKey
OUKWLRHRXOPODD-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Unc-0646
CAS: 1320288-17-2
CID: 53315882
Formula: C36H59N7O2
MW: 621.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight621.9
XLogP36.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count11
Exact Mass621.47302415
Monoisotopic Mass621.47302415
Topological Polar Surface Area69.2 Ų
Heavy Atom Count45
Formal Charge0
Complexity845
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
2606-5UNC0646
A13194-100UNC0646 100mg
A13194-50UNC0646 50mg
A13194-25UNC0646 25mg
A13194-5UNC0646 5mg
A13194-10UNC0646 10mg
A13194-10mM-DUNC0646 10mM * 1mL in DMSO
bs-60184C-01UNC0646 --- G9a/GLP HMTase Inhibitor

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