Pralsetinib

CAT: 0013-GTR19164477-02Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19164477-02Size:5 mg

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Description

Pralsetinib (BLU-667) is a potent and selective RET kinase inhibitor effective against wild-type RET, multiple mutants (V804L, V804M, M918T), and the CCDC6-RET fusion. It is a valuable research tool for investigating RET-driven pathologies, with demonstrated activity in both cellular assays and in vivo models of RET-altered cancers.

CAS Number

2097132-94-8

Product Name Alternative

Inhibitor, inhibit, cRET, Blu667, BLU-667, BLU 667, Pralsetinib, RET

Field of Research

Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Purity

97.88% (May vary between batches)

Solubility

10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.18 mM) ; DMSO:126.25 mg/mL (236.6 mM)

Smiles

CO[C@]1 (CC[C@@H] (CC1) c1nc (C) cc (Nc2cc (C) [nH]n2) n1) C (=O) N[C@@H] (C) c1ccc (nc1) -n1cc (F) cn1

Molecular Formula

C27H32FN9O2

Molecular Weight

533.6

Storage Conditions

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Notes

For research use only.

Chemical Information

Pralsetinib

See also: Pralsetinib (annotation moved to).

CAS Number	2097132-94-8
PubChem CID	129073603
IUPAC Name	N-[(1S)-1-[6-(4-fluoropyrazol-1-yl)-3-pyridinyl]ethyl]-1-methoxy-4-[4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]cyclohexane-1-carboxamide
Molecular Formula	C27H32FN9O2
Molecular Weight	533.6
XLogP	3.1
Topological Polar Surface Area	136
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	8
Heavy Atom Count	39
Formal Charge	0
Complexity	816

SMILES

CC1=CC(=NN1)NC2=NC(=NC(=C2)C)C3CCC(CC3)(C(=O)N[C@@H](C)C4=CN=C(C=C4)N5C=C(C=N5)F)OC

InChI

InChI=1S/C27H32FN9O2/c1-16-11-22(33-23-12-17(2)35-36-23)34-25(31-16)19-7-9-27(39-4,10-8-19)26(38)32-18(3)20-5-6-24(29-13-20)37-15-21(28)14-30-37/h5-6,11-15,18-19H,7-10H2,1-4H3,(H,32,38)(H2,31,33,34,35,36)/t18-,19?,27?/m0/s1

InChIKey

GBLBJPZSROAGMF-SIYOEGHHSA-N

Chemical Structure

2D Structure

CAS: 2097132-94-8

CID: 129073603

Formula: C27H32FN9O2

MW: 533.6

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	533.6
XLogP3	3.1
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	8
Exact Mass	533.26629946
Monoisotopic Mass	533.26629946
Topological Polar Surface Area	136 Å²
Heavy Atom Count	39
Formal Charge	0
Complexity	816
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
HY-112301-01	Pralsetinib
MBS3846014-01	cis-Pralsetinib
A19526-10	Pralsetinib 10mg
T10823	Trans-Pralsetinib
A19526-50	Pralsetinib 50mg
HY-112301R-01	Pralsetinib (Standard)
A19526-25	Pralsetinib 25mg
A19526-5	Pralsetinib 5mg
A19526-100	Pralsetinib 100mg
A19526-2	Pralsetinib 2mg

Pralsetinib

Chemical Information

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