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Birinapant

CAT: 0013-GTR19164154-08Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19164154-08Size:50 mg
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Description
Birinapant is a SMAC mimetic antagonist, mostly to cIAP1 with Kd of <1 nM, less potent to XIAP. Phase 2. (In Vitro) :Birinapant (TL32711) (30-10000 nM; 24 hours) significantly decreases the viability of SUM190 cells in a dose-dependent manner.Birinapant (TL32711) (30-1000 nM; 4 hours) shows a significant decrease in cIAP1 levels and enhanced PARP cleavage, and induces apoptosis.Birinapant (TL32711) binds with high affinity to the isolated BIR3 domains of cIAP1, cIAP2, and XIAP and the single BIR domain of ML-IAP and rapidly degrades TRAF2-bound cIAP1 and cIAP2 thereby inhibiting TNF-mediated NF-κB activation. (In Vivo) :Birinapant (TL32711) (30 mg/kg; i.p.; every third day (*5) ) shows antitumor efficacy and are devoid of overt toxicity in preclinical models.
CAS Number
1260251-31-7
Product Name Alternative
TL-32711
Purity
>98% (HPLC)
Solubility
DMSO:100 mg/mL (123.92 mM) ; Ethanol:55 mg/mL (68.15 mM) ; Water:<1 mg/mL (<1 mM)
Smiles
C[C@H] (NC) C (N[C@@H] (CC) C (N1[C@H] (CC2=C (C (N3) =C (C[C@H]4N (C ([C@@H] (NC ([C@@H] (NC) C) =O) CC) =O) C[C@@H] (O) C4) C5=C3C=C (F) C=C5) NC6=C2C=CC (F) =C6) C[C@H] (O) C1) =O) =O
Molecular Formula
C42H56F2N8O6
Molecular Weight
806.94
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(2S) -N-[ (2S) -1-[ (2R,4S) -2-[[6-fluoro-2-[6-fluoro-3-[[ (2R,4S) -4-hydroxy-1-[ (2S) -2-[[ (2S) -2- (methylamino) propanoyl]amino]butanoyl]pyrrolidin-2-yl]methyl]-1H-indol-2-yl]-1H-indol-3-yl]methyl]-4-hydroxypyrrolidin-1-yl]-1-oxobutan-2-yl]-2- (methylamino) propanamide

Chemical Information

Birinapant

Birinapant is a dipeptide.

CAS Number1260251-31-7
PubChem CID49836020
IUPAC Name(2S)-N-[(2S)-1-[(2R,4S)-2-[[6-fluoro-2-[6-fluoro-3-[[(2R,4S)-4-hydroxy-1-[(2S)-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]pyrrolidin-2-yl]methyl]-1H-indol-2-yl]-1H-indol-3-yl]methyl]-4-hydroxypyrrolidin-1-yl]-1-oxobutan-2-yl]-2-(methylamino)propanamide
Molecular FormulaC42H56F2N8O6
Molecular Weight806.9
XLogP3.3
Topological Polar Surface Area195
Hydrogen Bond Donor Count8
Hydrogen Bond Acceptor Count10
Rotatable Bond Count15
Heavy Atom Count58
Formal Charge0
Complexity1350
SMILES
CC[C@@H](C(=O)N1C[C@H](C[C@H]1CC2=C(NC3=C2C=CC(=C3)F)C4=C(C5=C(N4)C=C(C=C5)F)C[C@@H]6C[C@@H](CN6C(=O)[C@H](CC)NC(=O)[C@H](C)NC)O)O)NC(=O)[C@H](C)NC
InChI
InChI=1S/C42H56F2N8O6/c1-7-33(49-39(55)21(3)45-5)41(57)51-19-27(53)15-25(51)17-31-29-11-9-23(43)13-35(29)47-37(31)38-32(30-12-10-24(44)14-36(30)48-38)18-26-16-28(54)20-52(26)42(58)34(8-2)50-40(56)22(4)46-6/h9-14,21-22,25-28,33-34,45-48,53-54H,7-8,15-20H2,1-6H3,(H,49,55)(H,50,56)/t21-,22-,25-,26-,27-,28-,33-,34-/m0/s1
InChIKey
PKWRMUKBEYJEIX-DXXQBUJASA-N
Chemical Structure
2D Structure
2D structure of Birinapant
CAS: 1260251-31-7
CID: 49836020
Formula: C42H56F2N8O6
MW: 806.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight806.9
XLogP33.3
Hydrogen Bond Donor Count8
Hydrogen Bond Acceptor Count10
Rotatable Bond Count15
Exact Mass806.42908786
Monoisotopic Mass806.42908786
Topological Polar Surface Area195 Ų
Heavy Atom Count58
Formal Charge0
Complexity1350
Isotope Atom Count0
Defined Atom Stereocenter Count8
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BUP10037-01Birinapant
A4219-10Birinapant (TL32711)

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