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Birinapant

CAT: 0013-GTR19164154-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19164154-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Birinapant is a SMAC mimetic antagonist, mostly to cIAP1 with Kd of <1 nM, less potent to XIAP. Phase 2. (In Vitro) :Birinapant (TL32711) (30-10000 nM; 24 hours) significantly decreases the viability of SUM190 cells in a dose-dependent manner.Birinapant (TL32711) (30-1000 nM; 4 hours) shows a significant decrease in cIAP1 levels and enhanced PARP cleavage, and induces apoptosis.Birinapant (TL32711) binds with high affinity to the isolated BIR3 domains of cIAP1, cIAP2, and XIAP and the single BIR domain of ML-IAP and rapidly degrades TRAF2-bound cIAP1 and cIAP2 thereby inhibiting TNF-mediated NF-κB activation. (In Vivo) :Birinapant (TL32711) (30 mg/kg; i.p.; every third day (*5) ) shows antitumor efficacy and are devoid of overt toxicity in preclinical models.
CAS Number
1260251-31-7
Product Name Alternative
TL-32711
Purity
>98% (HPLC)
Solubility
DMSO:100 mg/mL (123.92 mM) ; Ethanol:55 mg/mL (68.15 mM) ; Water:<1 mg/mL (<1 mM)
Smiles
C[C@H] (NC) C (N[C@@H] (CC) C (N1[C@H] (CC2=C (C (N3) =C (C[C@H]4N (C ([C@@H] (NC ([C@@H] (NC) C) =O) CC) =O) C[C@@H] (O) C4) C5=C3C=C (F) C=C5) NC6=C2C=CC (F) =C6) C[C@H] (O) C1) =O) =O
Molecular Formula
C42H56F2N8O6
Molecular Weight
806.94
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(2S) -N-[ (2S) -1-[ (2R,4S) -2-[[6-fluoro-2-[6-fluoro-3-[[ (2R,4S) -4-hydroxy-1-[ (2S) -2-[[ (2S) -2- (methylamino) propanoyl]amino]butanoyl]pyrrolidin-2-yl]methyl]-1H-indol-2-yl]-1H-indol-3-yl]methyl]-4-hydroxypyrrolidin-1-yl]-1-oxobutan-2-yl]-2- (methylamino) propanamide

Alternative Products

CatalogName
BUP10037-01Birinapant
A4219-10Birinapant (TL32711)

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