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BAPTA-AM

CAT: 0013-GTR19164149-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19164149-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BAPTA-AM is a selective, membrane-permeable calcium chelator. (In Vitro) :BAPTA-AM inhibits neuronal Ca2+-activated K+ channel currents, and up-regulates the decreased cardiac sodium current (INa) density by chelating intracellular Ca2+.BAPTA-AM (BAPTA/AM), an intracellular calcium chelator, induces delayed necrosis by lipoxygenase-mediated free radicals in mouse cortical cultures. BAPTA-AM prevents free radical-mediated toxicity promote apoptosis in non-neuronal cells and produce a beneficial effect in neuronal cells by protecting neurons from ischemic damage. In addition, it has been suggested that BAPTA-AM induces a late, but not early, increase of intracellular calcium in I-IL-60 neoplastic cells. Mixed cortical cell cultures (DIV 13-16) exposed to 10 μM BAPTA-AM for 24- or 48-hr show moderate (45-70%) neuronal injury as evaluated by increased LDH release into the bathing medium after 24-48-hr. Exposure of cortical cultures to 3-10 μM BAPTA-AM for 48-hr evoke dose-dependent neuronal damage.
CAS Number
126150-97-8
Product Name Alternative
BAPTA Acetoxymethyl ester
Purity
>98% (HPLC)
Solubility
DMSO: 20 mg/mL (26.15 mM)
Smiles
O=C (OCOC (C) =O) CN (CC (OCOC (C) =O) =O) C1=CC=CC=C1OCCOC2=CC=CC=C2N (CC (OCOC (C) =O) =O) CC (OCOC (C) =O) =O
Molecular Formula
C34H40N2O18
Molecular Weight
764.68
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Acetyloxymethyl 2-[N-[2- (acetyloxymethoxy) -2-oxoethyl]-2-[2-[2-[bis[2- (acetyloxymethoxy) -2-oxoethyl]amino]phenoxy]ethoxy]anilino]acetate

Chemical Information

Bapta-AM

2-[N-[2-(acetyloxymethoxy)-2-oxoethyl]-2-[2-[2-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]phenoxy]ethoxy]anilino]acetic acid acetyloxymethyl ester is an alpha-amino acid ester.

CAS Number126150-97-8
PubChem CID2293
IUPAC Nameacetyloxymethyl 2-[N-[2-(acetyloxymethoxy)-2-oxoethyl]-2-[2-[2-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]phenoxy]ethoxy]anilino]acetate
Molecular FormulaC34H40N2O18
Molecular Weight764.7
XLogP3.4
Topological Polar Surface Area235
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count20
Rotatable Bond Count31
Heavy Atom Count54
Formal Charge0
Complexity1100
SMILES
CC(=O)OCOC(=O)CN(CC(=O)OCOC(=O)C)C1=CC=CC=C1OCCOC2=CC=CC=C2N(CC(=O)OCOC(=O)C)CC(=O)OCOC(=O)C
InChI
InChI=1S/C34H40N2O18/c1-23(37)47-19-51-31(41)15-35(16-32(42)52-20-48-24(2)38)27-9-5-7-11-29(27)45-13-14-46-30-12-8-6-10-28(30)36(17-33(43)53-21-49-25(3)39)18-34(44)54-22-50-26(4)40/h5-12H,13-22H2,1-4H3
InChIKey
YJIYWYAMZFVECX-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Bapta-AM
CAS: 126150-97-8
CID: 2293
Formula: C34H40N2O18
MW: 764.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight764.7
XLogP33.4
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count20
Rotatable Bond Count31
Exact Mass764.22761243
Monoisotopic Mass764.22761243
Topological Polar Surface Area235 Ų
Heavy Atom Count54
Formal Charge0
Complexity1100
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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