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BAPTA-AM

CAT: 0013-GTR19164149-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19164149-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BAPTA-AM is a selective, membrane-permeable calcium chelator. (In Vitro) :BAPTA-AM inhibits neuronal Ca2+-activated K+ channel currents, and up-regulates the decreased cardiac sodium current (INa) density by chelating intracellular Ca2+.BAPTA-AM (BAPTA/AM), an intracellular calcium chelator, induces delayed necrosis by lipoxygenase-mediated free radicals in mouse cortical cultures. BAPTA-AM prevents free radical-mediated toxicity promote apoptosis in non-neuronal cells and produce a beneficial effect in neuronal cells by protecting neurons from ischemic damage. In addition, it has been suggested that BAPTA-AM induces a late, but not early, increase of intracellular calcium in I-IL-60 neoplastic cells. Mixed cortical cell cultures (DIV 13-16) exposed to 10 μM BAPTA-AM for 24- or 48-hr show moderate (45-70%) neuronal injury as evaluated by increased LDH release into the bathing medium after 24-48-hr. Exposure of cortical cultures to 3-10 μM BAPTA-AM for 48-hr evoke dose-dependent neuronal damage.
CAS Number
126150-97-8
Product Name Alternative
BAPTA Acetoxymethyl ester
Purity
>98% (HPLC)
Solubility
DMSO: 20 mg/mL (26.15 mM)
Smiles
O=C (OCOC (C) =O) CN (CC (OCOC (C) =O) =O) C1=CC=CC=C1OCCOC2=CC=CC=C2N (CC (OCOC (C) =O) =O) CC (OCOC (C) =O) =O
Molecular Formula
C34H40N2O18
Molecular Weight
764.68
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Acetyloxymethyl 2-[N-[2- (acetyloxymethoxy) -2-oxoethyl]-2-[2-[2-[bis[2- (acetyloxymethoxy) -2-oxoethyl]amino]phenoxy]ethoxy]anilino]acetate

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