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HSP70-IN-27c

CAT: 0013-GTR19164131-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19164131-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HSP70-IN-27c is a potent, irreversible inhibitor of Hsp70 without Hsp 90 binding activity, inhibits growth of Kasumi-1 AML cells with IC50 of 2.3 uM, and inhibits Caspase-3,7 activation in MOLM13 AML cells with IC50 of 1.9 uM; inhibits HER2 and Raf-1 steady-state levels, PARP cleavage in SKBr3 breast cancer cells with IC50 of about 1.5 uM, induces apoptosis in MDA-MB-468 cells.
CAS Number
1268273-90-0
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
CN1CCN (CC1) C2=NC=C (C (=N2) OCC3=CC=CC=C3) SC4=CC=CC (=C4) NC (=O) CN
Molecular Formula
C24H28N6O2S
Molecular Weight
464.5831
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Acetamide, 2-amino-N-[3-[[2- (4-methyl-1-piperazinyl) -4- (phenylmethoxy) -5-pyrimidinyl]thio]phenyl]-

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