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(±) -Bisoprolol hemifumarate

CAT: 0013-GTR19163992-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163992-01Size:100 mg
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Description
Bisoprolol is a selective type β1 adrenergic receptor blocker. (In Vitro) :Bisoprolol hemifumarate (2 μM, 1 h) protects myocardial cells (H9c2) from ischemia/reperfusion (I/R) injury.Bisoprolol hemifumarate (2 μM, 1 h) reduces the H/R-induced ROS production and apoptosis in H9c2 cells.Bisoprolol hemifumarate (2 μM, 1 h) increases AKT and GSK3β phosphorylation in H9c2 cells.Bisoprolol hemifumarate (100 μM, 24 h) reverses Epinephrine-inhibited emigration in cholesterol-loaded DCs (dendritic cell) through increasing in β-arrestin 2, CCR7 and PI3K phosphorylation. (In Vivo) :Bisoprolol hemifumarate (oral administration, 5 mg/kg, for 1 week) increases left ventricular ejection fraction (LVEF) and decreases the heart rate value.Bisoprolol hemifumarate (oral gavage, 8 mg/kg, daily for four weeks) shows protective effects against Cadmium-induced myocardial toxicity in rats.Bisoprolol hemifumarate (oral gavage, 1 mg/kg, daily for 6 weeks) reversessmall conductance calcium-activated potassium channel (SK) remodeling in a volume-overload rat model.
CAS Number
104344-23-2
Product Name Alternative
Bisoprolol hemifumarate | Zebeta | (+/-) -Bisoprolol hemifumarate | Bisobloc | Fumarate, Bisoprolol
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Ethanol: 88 mg/mL (199.31 mM) ; Water: 88 mg/mL (199.31 mM) ; DMSO: 88 mg/mL (199.31 mM)
Smiles
CC (C) NCC (COC1=CC=C (C=C1) COCCOC (C) C) O.CC (C) NCC (COC1=CC=C (C=C1) COCCOC (C) C) O.C (=CC (=O) O) C (=O) O
Molecular Formula
C20H33NO6
Molecular Weight
383.49
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(E) -but-2-enedioic acid;1- (propan-2-ylamino) -3-[4- (2-propan-2-yloxyethoxymethyl) phenoxy]propan-2-ol