Products for Research Use Only
RegisterLogin

LDN193189

CAT: 0013-GTR19163963-02Size: 1 gDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19163963-02Size:1 g
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
LDN193189 is a potent, selective BMP type I receptor that inhibits BMP4-induced phosphorylation of SMAD1/5/8 with IC50 of 5 nM, displays >200-fold selectivity for BMP signaling over TGF-β signaling (IC50>1,000 nM) ; efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 (IC50=5 nM and 30 nM, respectively), with weaker effects on activin and the TGF-β type I receptors ALK4, ALK5 and ALK7; also blocks the transcriptional activity induced by either constitutively active ALK2 R206H or ALK2 Q207D mutant proteins, affects BMP-induced osteoblast differentiation, attenuates ectopic ossification in vivo. (In Vitro) :LDN193189 (GMP) (250 nM; 0-7 d) induces human pluripotent stem cells (hPSC) directly differentiates into midbrain dopamine neurons (mDA) .LDN193189 (GMP) (200 nM) induces the generation of glucose-responsive β cells from hPSCs in vitro.
CAS Number
1062368-24-4
Product Name Alternative
LDN 193189 | LDN-193189 | DM-3189
Purity
>98% (HPLC)
Solubility
Ethanol: 0.25 mg/mL (Need ultrasonic and warming) ; DMSO: < 0.1 mg/mL; H2O: < 0.1 mg/mL
Smiles
C1CN (CCN1) C1=CC=C (C=C1) C1=CN2N=CC (=C2N=C1) C1=CC=NC2=CC=CC=C12
Molecular Formula
C25H22N6
Molecular Weight
406.4824
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Quinoline, 4-[6-[4- (1-piperazinyl) phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-

Chemical Information

4-(6-(4-(1-Piperazinyl)phenyl)pyrazolo(1,5-a)pyrimidin-3-yl)quinoline

4-[6-[4-(1-piperazinyl)phenyl]-3-pyrazolo[1,5-a]pyrimidinyl]quinoline is a member of pyrimidines.

CAS Number1062368-24-4
PubChem CID25195294
IUPAC Name4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline
Molecular FormulaC25H22N6
Molecular Weight406.5
XLogP3.3
Topological Polar Surface Area58.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Heavy Atom Count31
Formal Charge0
Complexity587
SMILES
C1CN(CCN1)C2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC6=CC=CC=C56)N=C3
InChI
InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2
InChIKey
CDOVNWNANFFLFJ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4-(6-(4-(1-Piperazinyl)phenyl)pyrazolo(1,5-a)pyrimidin-3-yl)quinoline
CAS: 1062368-24-4
CID: 25195294
Formula: C25H22N6
MW: 406.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight406.5
XLogP33.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Exact Mass406.19059473
Monoisotopic Mass406.19059473
Topological Polar Surface Area58.4 Ų
Heavy Atom Count31
Formal Charge0
Complexity587
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS696259-01LDN193189
HY-12071G-01LDN193189 (GMP)
1995-25LDN193189 HCl
MBS3846304-01LDN193189 Tetrahydrochloride
A11205-1000LDN193189 1g
A11205-5LDN193189 5mg
A3545-10LDN193189 Hydrochloride
HY-12071C-01LDN193189 (hydrochloride)
B3074-5EZSolution™ LDN193189
A11205-100LDN193189 100mg

Popular Products