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LDN193189

CAT: 0013-GTR19163963-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163963-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LDN193189 is a potent, selective BMP type I receptor that inhibits BMP4-induced phosphorylation of SMAD1/5/8 with IC50 of 5 nM, displays >200-fold selectivity for BMP signaling over TGF-β signaling (IC50>1,000 nM) ; efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 (IC50=5 nM and 30 nM, respectively), with weaker effects on activin and the TGF-β type I receptors ALK4, ALK5 and ALK7; also blocks the transcriptional activity induced by either constitutively active ALK2 R206H or ALK2 Q207D mutant proteins, affects BMP-induced osteoblast differentiation, attenuates ectopic ossification in vivo. (In Vitro) :LDN193189 (GMP) (250 nM; 0-7 d) induces human pluripotent stem cells (hPSC) directly differentiates into midbrain dopamine neurons (mDA) .LDN193189 (GMP) (200 nM) induces the generation of glucose-responsive β cells from hPSCs in vitro.
CAS Number
1062368-24-4
Product Name Alternative
LDN 193189 | LDN-193189 | DM-3189
Purity
>98% (HPLC)
Solubility
Ethanol: 0.25 mg/mL (Need ultrasonic and warming) ; DMSO: < 0.1 mg/mL; H2O: < 0.1 mg/mL
Smiles
C1CN (CCN1) C1=CC=C (C=C1) C1=CN2N=CC (=C2N=C1) C1=CC=NC2=CC=CC=C12
Molecular Formula
C25H22N6
Molecular Weight
406.4824
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Quinoline, 4-[6-[4- (1-piperazinyl) phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-

Alternative Products

CatalogName
MBS696259-01LDN193189
HY-12071G-01LDN193189 (GMP)
A3545-10LDN193189 Hydrochloride
1995-25LDN193189 HCl
MBS3846304-01LDN193189 Tetrahydrochloride
A11205-1000LDN193189 1g
A11205-5LDN193189 5mg
HY-12071C-01LDN193189 (hydrochloride)
B3074-5EZSolution™ LDN193189
A11205-100LDN193189 100mg

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