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Ursodeoxycholic acid

CAT: 0013-GTR19163931Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19163931Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ursodiol reduces cholesterol absorption and is used to dissolve gallstones. (In Vitro) :Ursodeoxycholic acid (10 μM; 24 h) reduces ACE2 and SHP levels in primary airway and intestinal organoids, and reduces SARS-CoV-2 infection in multiple cell types via FXR-mediated ACE2 regulation. (In Vivo) :Ursodeoxycholic acid (50, 150, and 450 mg/kg; p.o.; daily for 21 days) results in weight loss in C57BL/6J wildtype mice.Ursodeoxycholic acid (1% w/w or 416 mg/kg; oral; 7 days) reduces ACE2 expression in mice and hamsters.Ursodeoxycholic acid (416 mg/kg; oral; 7 days) reduces SARS-CoV-2 infection in hamsters.
CAS Number
128-13-2
Purity
>98% (HPLC)
Solubility
Ethanol: 79 mg/mL (201.23 mM) ; DMSO: 79 mg/mL (201.23 mM)
Smiles
C[C@H] (CCC (=O) O) [C@H]1CC[C@@H]2[C@@]1 (CC[C@H]3[C@H]2[C@H] (C[C@H]4[C@@]3 (CC[C@H] (C4) O) C) O) C
Molecular Formula
C24H40O4
Molecular Weight
392.57
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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