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Romidepsin

CAT: 0013-GTR19163926-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163926-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Romidepsin (FK228, depsipeptide) is a potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM, respectively. (In Vitro) :Romidepsin (0-72 hours; 0-80 nM) inhibits proliferation of HCC cells in dose-dependent manner.Romidepsin (0-48 hours; 0-60 nM) leads to a time- and dose-dependent induction of cell cycle arrest in the G2/M phase in HCC cells.Romidepsin (0-48 hours; 0-60 nM) promotesapoptosis in HCC cells, increases c-caspase-3, c-caspase-9, and c-PARP protein expression. (In Vivo) :Romidepsin (intraperitoneal injection; 0.5 and 1 mg/kg; every 3 day; 21 days) inhibited the tumor growth, reveals a higher expression of p-cdc25C, ki67, c-caspase-3 and c-PARP, and a lower expression of Ki-67 in Romidepsin treated tumors .
CAS Number
128517-07-7
Product Name Alternative
FK228, Depsipeptide
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO: 10 mg/mL (18.49 mM)
Smiles
O=C ([C@H] (C (C) C) NC (/C (N1) =C/C) =O) O[C@] (CC (N[C@H] (C (C) C) C (N2) =O) =O) ([H]) /C=C/CCSSC[C@]2 ([H]) C1=O
Molecular Formula
C24H36N4O6S2
Molecular Weight
540.7
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(1S,4S,7Z,10S,16E,21R) -7-ethylidene-4,21-bis (1methylethyl) -2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricos-16ene-3,6,9,19,22-pentone

Alternative Products

CatalogName
TRC-R425060-10MGRomidepsin
HY-15149GRomidepsin (GMP)
MBS516378-01Romidepsin (FK228)
CS-T-96294Romidepsin-d8

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