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GSK503

CAT: 0013-GTR19163784-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19163784-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GSK503 is a potent, specific EZH2 methyltransferase inhibitor that inhibits the methyltransferase activity of WT and mutant EZH2 with similar potency (Ki app=3-27 nM) ; GSK503 is highly selective for the SET domain of EZH2, >200 fold selective over EZH1 and > 4000 fold selective over other HMTases; inhibits GCB lymphoma cell lines with IC50 of 0.5-20 uM; impairs proliferation and invasiveness, accompanied by re-expression of tumour suppressor in melanoma cells; stabilizes the disease through inhibition of growth and virtually abolishes metastases formation without affecting normal melanocyte biology in melanoma mouse model.
CAS Number
1346572-63-1
Product Name Alternative
GSK-503
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 44 mg/mL
Smiles
O=C (C1=CC (C2=CC=C (N3CCN (C) CC3) N=C2) =CC4=C1C (C) =CN4C (C) C) NCC5=C (C) C=C (C) NC5=O
Molecular Formula
C31H38N6O2
Molecular Weight
526.6724
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1H-Indole-4-carboxamide, N-[ (1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl) methyl]-3-methyl-1- (1-methylethyl) -6-[6- (4-methyl-1-piperazinyl) -3-pyridinyl]-

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