Hexylresorcinol

Hexylresorcinol is an organic compound with local anaesthetic, antiseptic and anthelmintic properties, is a potent inhibitor of mushroom tyrosinase, causing 90% loss of activity at 100 μM. (In Vitro) :Hexylresorcinol potently inhibits Gram positive bacteria, with MICs of 20-50 mg/L for several Gram positive bacteria. Gram negative bacteria, yeasts and fungi are less sensitive to it.Hexylresorcinol inhibits oxidative DNA damage in human lymphocytes by increasing levels of glutathione and modulation of antioxidant enzymes (GPX, GR and GST) .Hexylresorcinol (1-10 μg/mL; 24-72 hours) suppresses squamous carcinoma cell line SCC-9 proliferation.Hexylresorcinol has strong antitumor effects by inhibiting calcium channel oscillation and inducing apoptosis.Hexylresorcinol upregulates TGF-β/SMAD/VEGF signaling in endothelial cells and induces vascular regeneration and remodeling for wound healing. (In Vivo) :Hexylresorcinol (10 mg/kg; i.p.; daily; for 16 days) inhibits tumor cell proliferation in mouse tumor xenografts and concomitant application of calcium channel blocker partly reverses the antitumor effect of Hexylresorcinol.

136-77-6

Hexylresorcinol | Ascaricid | Ascarinol | Ascaryl | NSC 1570

Pharmacology & Drug Discovery

>98% (HPLC)

Water: 500 mg/L at 18 °C.

OC1=CC=C (CCCCCC) C (O) =C1

C12H18O2

194.27

Storage temperature: -20°C. Stability: ≥ 2 years

For research use only.