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Noradrenaline bitartrate monohydrate

CAT: 0013-GTR19163698-01Size: 200 mgDry Ice: NoHazardous: No
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Description
Noradrenaline bitartrate monohydrate is a direct alpha-adrenergic receptors stimulator. (In Vitro) :Norepinephrine (Levarterenol; L-Noradrenaline) bitartrate monohydrate is generally considered to be a β1-subtype selective adrenergic agonist over β2-adrenoceptor. Norepinephrine (NE) bitartrate monohydrate also has direct activity at the β2-adrenoceptor in higher concentrations.Adipocytes from the inguinal fat pad (iWA) or the interscapular fat pad (BA) are isolated from neonatal wild-type C57BL/6J mice and cultured. To examine the effect of activating AT2 upon β-adrenergic signaling, cAMP production is first assessed in response to Norepinephrine (NE, 10 μM) with or without CGP (10 nM) co-treatment.Norepinephrine (NE) increases cAMP as expected in iWA, and CGP does not alter this effect.Norepinephrine (NE) is also known to induce lipolysis, and liberated fatty acids are required to functionally activate UCP1 protein and to stimulate heat production. CREB phosphorylation at Ser133 is increased after Norepinephrine (NE) treatment and significantly attenuated with CGP co-treatment in mouse iWA.
CAS Number
108341-18-0
Product Name Alternative
Arterenol | Levarterenol | NE | L-Noradrenaline
Purity
>98% (HPLC)
Solubility
Water: 64 mg/mL (189.75 mM) ; DMSO: 64 mg/mL (189.75 mM)
Smiles
C1=CC (=C (C=C1[C@H] (CN) O) O) O.[C@@H] ([C@H] (C (=O) O) O) (C (=O) O) O.O
Molecular Formula
C8H11NO3·C4H6O6·H2O
Molecular Weight
337.28
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Chemical Information

Norepinephrine Bitartrate

Norepinephrine Bitartrate is a bitartrate salt of norepinephrine, a synthetic phenylethylamine that mimics the sympathomimetic actions of the endogenous norepinephrine. Norepinephrine bitartrate acts directly on the alpha- and beta-adrenergic receptors. Clinically, norepinephrine is used as a peripheral vasoconstrictor that causes constriction of arterial and venous beds via its alpha-adrenergic action. It is also used as a potent inotropic and chronotropic stimulator of the heart mediated through its beta-1 adrenergic action.

CAS Number108341-18-0
PubChem CID3047796
IUPAC Name4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol;(2R,3R)-2,3-dihydroxybutanedioic acid;hydrate
Molecular FormulaC12H19NO10
Molecular Weight337.28
Topological Polar Surface Area203
Hydrogen Bond Donor Count9
Hydrogen Bond Acceptor Count11
Rotatable Bond Count5
Heavy Atom Count23
Formal Charge0
Complexity276
SMILES
C1=CC(=C(C=C1[C@H](CN)O)O)O.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O.O
InChI
InChI=1S/C8H11NO3.C4H6O6.H2O/c9-4-8(12)5-1-2-6(10)7(11)3-5;5-1(3(7)8)2(6)4(9)10;/h1-3,8,10-12H,4,9H2;1-2,5-6H,(H,7,8)(H,9,10);1H2/t8-;1-,2-;/m01./s1
InChIKey
LNBCGLZYLJMGKP-LUDZCAPTSA-N
Chemical Structure
2D Structure
2D structure of Norepinephrine Bitartrate
CAS: 108341-18-0
CID: 3047796
Formula: C12H19NO10
MW: 337.28
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight337.28
Hydrogen Bond Donor Count9
Hydrogen Bond Acceptor Count11
Rotatable Bond Count5
Exact Mass337.10089580
Monoisotopic Mass337.10089580
Topological Polar Surface Area203 Ų
Heavy Atom Count23
Formal Charge0
Complexity276
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count3
Compound Is CanonicalizedYes

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