Products for Research Use Only
RegisterLogin

Zosuquidar trihydrochloride

CAT: 0013-GTR19163546-01Size: 100 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19163546-01Size:100 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
A potent P-glycoprotein (P-gp) inhibitor with Ki of 60 nM; fully restores sensitivity to vinblastine, doxorubicin, etoposide, and Taxol in CEM/VLB100 cells at 0.1 uM; enhances the antitumor activity of Taxol in a MDR human non-small cell lung carcinoma nude mouse xenograft model.Blood Cancer Phase 3 Discontinued (In Vitro) :Zosuquidar (0.3 μM; 48 h) enhances the cytotoxicity of DNR (substrates for P-glycoproteins) in P-glycoproteins active cell lines.Zosuquidar (5-16 μM; 72 h) treatment alone shows high cytotoxic concentration to drug-sensitive and MDR cell lines. (In Vivo) :Zosuquidar (intraperitoneal injection; 30, 10, 3, or 1 mg/kg; once daily; 5 d) treatment shows a significant increase in life span.Zosuquidar (intraperitoneal injection; 30 mg/kg; once daily; 5 d) treatment shows the potentiation with a combined of Doxorubicin.
CAS Number
167465-36-3
Product Name Alternative
LY-335979 trihydrochloride
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
FC1 ([C@H]2[C@@H]1C3=C ([C@@H] (C4=CC=CC=C42) N5CCN (CC5) C[C@H] (COC6=C7C=CC=NC7=CC=C6) O) C=CC=C3) F.Cl.Cl.Cl
Molecular Formula
C32H34Cl3F2N3O2
Molecular Weight
636.9871
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1-Piperazineethanol, 4-[ (1a.alpha.,6.alpha.,10b.alpha.) -1,1-difluoro-1,1a,6,10b-tetrahydrodibenzo[a, e]cyclopropa[c]cyclohepten-6-yl]-.alpha.-[ (5-quinolinyloxy) methyl]-, hydrochloride (1:3), (.alpha.R) -

Related Products

CatalogName
GTR19188253-01Zosuquidar
GTR19212917-01CBB1007 trihydrochloride
GTR19210110-01NG25 trihydrochloride
GTR19207224-01Mavorixafor trihydrochloride
GTR19205686Gusperimus trihydrochloride
GTR19191421Spergualin trihydrochloride
GTR19226536-01Tazemetostat trihydrochloride
GTR19247782-01NOTA trihydrochloride
GTR19172397-01LY2409881 trihydrochloride
GTR19166774-01Ninerafaxstat trihydrochloride

Alternative Products

CatalogName
FZ28787-01Zosuquidar trihydrochloride
HY-50671-01Zosuquidar (trihydrochloride)
HY-50671R-01Zosuquidar (trihydrochloride) (Standard)
MBS578594Zosuquidar (LY335979) triHydrochloride
TRC-Z700872-75MGrac Zosuquidar-d5 Trihydrochloride
HY-15255-01Zosuquidar

Popular Products