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PD98059

CAT: 0013-GTR19163542-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163542-01Size:500 mg
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Description
PD98059 (PD 098059) is a specific MEK inhibitor with IC50 of ~10 uM without significant inhibitory activity of MAPK; prevents activation of MAPK and subsequent phosphorylation of MAPK substrates both in vitro and in intact cells. (In Vitro) :PD98059 (20 μM; 24 hours) causes G1-phase cell cycle arrest in OCI-AML-3 cells.PD98059 (10 μM; 22 hours) results in concentration-dependent reductions in the dually phosphorylated forms of ERK1 and ERK2. PD98059 both prevents ERK activation and blocks formation of TDP-43 and HuR-positive SGs. (In Vivo) :PD98059 (10 mg/kg; i.p.; 1 and 6 hours after Zymosan) significantly reduces the level of p-ERK1/2 in zymosan-injected mice.
CAS Number
167869-21-8
Product Name Alternative
PD 098059 | PD-98059
Purity
>98% (HPLC)
Solubility
DMSO: 16 mg/mL; H2O: < 0.01 mg/mL
Smiles
O=C1C=C (C2=CC=CC (OC) =C2N) OC3=C1C=CC=C3
Molecular Formula
C16H13NO3
Molecular Weight
267.2793
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4H-1-Benzopyran-4-one, 2- (2-amino-3-methoxyphenyl) -

Alternative Products

CatalogName
A1663-100PD98059

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