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TPEN

CAT: 0013-GTR19163536-05Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163536-05Size:100 mg
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Description
TPEN is a specific cell-permeable heavy metal chelator. (In Vitro) :Heavy metal chelator TPEN attenuates fura-2 fluorescence changes induced by cadmium, mercury and methylmercury. TPEN, a cell-permeable chelator for heavy metal cations with a low affinity for Ca2+. In cells stimulated with 10 or 30 μM cadmium chloride, the addition of TPEN at 3 hr after exposure significantly decreases the elevated fura-2 fluorescence ratio to the basal levels within 10 min (119.6±2.4% or 109±1.5% decrease in ΔRatio (F340/F380) induced by 10 or 30 μM cadmium chloride, respectively), suggesting that a cadmium chloride-induced increase in the fura-2 fluorescence ratio is dependent on an increase in intracellular heavy metal cations but not intracellular Ca2+. TPEN is a metal chelator, which targets colon cancer cells through redox cycling of copper. TPEN reduces cell viability in a dose- and time-dependent manner. TPEN-induced cell death is also dependent on the redox cycling of copper since the copper chelator neocuproine inhibited DNA damage and reduced pChk1, γ-H2AX, and ATM protein expression. Cell death by low TPEN concentrations, involved ATM/ATR signaling in all 3 cell lines, since pre-incubation with specific inhibitors of ATM and DNA-PK led to the recovery of cells from TPEN-induced DNA damage.
CAS Number
16858-02-9
Product Name Alternative
TPEDA
Purity
>98% (HPLC)
Solubility
DMSO:10 mM
Smiles
N (CC1=NC=CC=C1) (CC2=NC=CC=C2) CCN (CC3=NC=CC=C3) CC4=NC=CC=C4
Molecular Formula
C26H28N6
Molecular Weight
424.552
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N, N, N', N'-tetrakis (2-pyridinylmethyl) -1,2-ethanediamine

Chemical Information

N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine is an N-substituted diamine that is ethylenediamine in which the four amino hydrogens are replaced by 2-pyridylmethyl groups. It has a role as a copper chelator, a chelator and an apoptosis inducer. It is a member of pyridines, a N-substituted diamine and a tertiary amino compound. It is functionally related to an ethylenediamine.

CAS Number16858-02-9
PubChem CID5519
IUPAC NameN,N,N',N'-tetrakis(pyridin-2-ylmethyl)ethane-1,2-diamine
Molecular FormulaC26H28N6
Molecular Weight424.5
XLogP2.1
Topological Polar Surface Area58
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count11
Heavy Atom Count32
Formal Charge0
Complexity419
SMILES
C1=CC=NC(=C1)CN(CCN(CC2=CC=CC=N2)CC3=CC=CC=N3)CC4=CC=CC=N4
InChI
InChI=1S/C26H28N6/c1-5-13-27-23(9-1)19-31(20-24-10-2-6-14-28-24)17-18-32(21-25-11-3-7-15-29-25)22-26-12-4-8-16-30-26/h1-16H,17-22H2
InChIKey
CVRXLMUYFMERMJ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine
CAS: 16858-02-9
CID: 5519
Formula: C26H28N6
MW: 424.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight424.5
XLogP32.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count11
Exact Mass424.23754492
Monoisotopic Mass424.23754492
Topological Polar Surface Area58 Ų
Heavy Atom Count32
Formal Charge0
Complexity419
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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A11980-100TPEN TPEN (TPEDA)
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HY-100202RTPEN (Standard)
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A11980-1000TPEN (TPEDA) 1000mg
A11980-500TPEN (TPEDA) 500mg

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