TA-02

CAT: 0013-GTR19163475-02Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19163475-02Size:5 mg

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Description

A potent p38 MAPK inhibitor with IC50 of 20 nM; inhibits the phosphorylation of proteins downstream of p38α MAPK such as MAPKAPK2 and HSP27 during cardiogenesis, and increases ATF-2 and MEF2C during cardiac differentiation. (In Vitro) :TA-02 (5 μM) inhibits the phosphorylation of proteins downstream of p38α MAPK such as MAPKAPK2 and HSP27 during cardiogenesis. TA-02 at 5 μM concentration induces cardiogenesis, but also increases ATF-2 phosphorylation and MEF2C expression in contrast to what would be expected with a mechanism dependent on p38α MAPK inhibition.TA-02 induces T/Brachyury whereas SB203580 addition increased MESP1 and T/Brachyury transcripts.TA-02 significantly induces high NKX2-5 expression when applied between days 0-8.TA-02 is found to inhibit multiple targets with similar potency to p38α MAPK, such as p38α, p38β, JNK3, JNK2, CIT, CK1ε, DMPK2, JNK1, DDR1 CK1δ, MEK5, and ERBB2.TA-02 and SB203580 reduce the nuclear TCF/LEF-1 driven transcription of luciferase similar to DKK-1.TA-02 (5 nM-5 μM) inhibits p38 and increases the anti-inflammation effects of BDNF on inflammation in vitro.

CAS Number

1784751-19-4

Product Name Alternative

TA02 | TA 02

Purity

>98% (HPLC)

Solubility

10 mM in DMSO

Smiles

FC1=CC=C (C2=C (C3=CC=NC=C3) NC (C4=CC=CC=C4F) =N2) C=C1

Molecular Formula

C20H13F2N3

Molecular Weight

333.3341

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

Pyridine, 4-[2- (2-fluorophenyl) -4- (4-fluorophenyl) -1H-imidazol-5-yl]-

Chemical Information

4-(2-(2-Fluorophenyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl)pyridine

CAS Number	1784751-19-4
PubChem CID	91691130
IUPAC Name	4-[2-(2-fluorophenyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]pyridine
Molecular Formula	C20H13F2N3
Molecular Weight	333.3
XLogP	4.2
Topological Polar Surface Area	41.6
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	3
Heavy Atom Count	25
Formal Charge	0
Complexity	421

SMILES

C1=CC=C(C(=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F)F

InChI

InChI=1S/C20H13F2N3/c21-15-7-5-13(6-8-15)18-19(14-9-11-23-12-10-14)25-20(24-18)16-3-1-2-4-17(16)22/h1-12H,(H,24,25)

InChIKey

QIFJOFNVIVQRNJ-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 1784751-19-4

CID: 91691130

Formula: C20H13F2N3

MW: 333.3

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	333.3
XLogP3	4.2
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	3
Exact Mass	333.10775375
Monoisotopic Mass	333.10775375
Topological Polar Surface Area	41.6 Å²
Heavy Atom Count	25
Formal Charge	0
Complexity	421
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Alternative Products

Catalog	Name
BUP13271-01	TA-02
B4924-5.1	TA 02
A13644-100	TA-02 100mg
A13644-10	TA-02 10mg
A13644-5	TA-02 5mg
A13644-50	TA-02 50mg
HY-100115R	TA-02 (Standard)
A13644-25	TA-02 25mg
A13644-10mM-D	TA-02 10mM * 1mL in DMSO
HY-176913	TA

TA-02

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