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AZD-0156

CAT: 0013-GTR19163431-02Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163431-02Size:2 mg
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Description
AZD-0156 (AZD0156, AZD 0156) is a potent, highly selective and orally bioavailable ATM inhibitor; exhibits antitumoral activity, both reducing tumor burden and preventing tumors from growing in an immunocompetent allograft mouse model of AML.Solid Tumors Phase 1 Clinical (In Vitro) :AZD0156 inhibits the kinase activity of ATM and ATM-mediated signaling, prevents DNA damage checkpoint activation, and disrupts DNA damage repair, inducs tumor cell apoptosis, and leads to cell death in ATM-overexpressing tumor cells.
CAS Number
1821428-35-6
Product Name Alternative
AZD0156 | AZD 0156
Purity
>98% (HPLC)
Solubility
DMSO: 6.2 mg/mL (Need ultrasonic and warming)
Smiles
O=C (N1C2CCOCC2) N (C) C3=C1C4=CC (C5=CC=C (OCCCN (C) C) N=C5) =CC=C4N=C3
Molecular Formula
C26H31N5O3
Molecular Weight
461.556
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2H-Imidazo[4,5-c]quinolin-2-one, 8-[6-[3- (dimethylamino) propoxy]-3-pyridinyl]-1,3-dihydro-3-methyl-1- (tetrahydro-2H-pyran-4-yl) -

Chemical Information

Azd-0156

ATM Kinase Inhibitor AZD0156 is an orally bioavailable ataxia telangiectasia mutated (ATM) kinase inhibitor, with potential chemo-/radio-sensitizing and antineoplastic activities. Upon oral administration, AZD0156 targets and binds to ATM, thereby inhibiting the kinase activity of ATM and ATM-mediated signaling. This prevents DNA damage checkpoint activation, disrupts DNA damage repair, induces tumor cell apoptosis, and leads to cell death of ATM-overexpressing tumor cells. In addition, AZD0156 sensitizes tumor cells to chemo- and radiotherapy. ATM, a serine/threonine protein kinase, is upregulated in a variety of cancer cell types; it is activated in response to DNA damage and plays a key role in DNA-strand repair.

CAS Number1821428-35-6
PubChem CID118502708
IUPAC Name8-[6-[3-(dimethylamino)propoxy]-3-pyridinyl]-3-methyl-1-(oxan-4-yl)imidazo[4,5-c]quinolin-2-one
Molecular FormulaC26H31N5O3
Molecular Weight461.6
XLogP2.9
Topological Polar Surface Area71
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count7
Heavy Atom Count34
Formal Charge0
Complexity687
SMILES
CN1C2=CN=C3C=CC(=CC3=C2N(C1=O)C4CCOCC4)C5=CN=C(C=C5)OCCCN(C)C
InChI
InChI=1S/C26H31N5O3/c1-29(2)11-4-12-34-24-8-6-19(16-28-24)18-5-7-22-21(15-18)25-23(17-27-22)30(3)26(32)31(25)20-9-13-33-14-10-20/h5-8,15-17,20H,4,9-14H2,1-3H3
InChIKey
AOTRIQLYUAFVSC-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Azd-0156
CAS: 1821428-35-6
CID: 118502708
Formula: C26H31N5O3
MW: 461.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight461.6
XLogP32.9
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count7
Exact Mass461.24268987
Monoisotopic Mass461.24268987
Topological Polar Surface Area71 Ų
Heavy Atom Count34
Formal Charge0
Complexity687
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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