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Cabazitaxel

CAT: 0013-GTR19163426-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163426-01Size:100 mg
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Description
A semi-synthetic taxane and microtubule inhibitor for the treatment of hormone-refractory prostate cancer; possesses a favorable pharmacokinetic and safety profile, and a decreased propensity for P-glycoprotein (Pgp) -mediated drug resistance.Chemotherapeutic Agents Approved (In Vitro) :The cytotoxicity of cabazitaxel (100 μg/mL) on 4T1 cells without irradiation is 70.8%. Cabazitaxel (100 μg/mL) exhibits a concentration-dependent antiproliferation effect, with the antiproliferative activity of 56.2%. (In Vivo) :Cabazitaxel (10 mg/kg, i.v.) has certain toxicity to liver and kidney but it can be avoided by integrated into Ans. The body weights of mice treated with AN-ICG-CBX and AN-CBX have a slightly decrease, while body weights of the free CBX group significantly decrease compared to the control group.
CAS Number
183133-96-2
Product Name Alternative
XRP6258 | XRP 6258
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO: 93 mg/mL (111.3 mM) ; Ethanol: <1 mg/mL; Water: <1 mg/mL (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
O=C (O[C@@H] ([C@@]1 ([H]) [C@@]2 (C) [C@@H] (OC) C[C@@]3 ([H]) OC[C@]31OC (C) =O) [C@]4 (O) C[C@H] (OC ([C@H] (O) [C@@H] (NC (OC (C) (C) C) =O) C5=CC=CC=C5) =O) C (C) =C (C4 (C) C) [C@@H] (OC) C2=O) C6=CC=CC=C6
Molecular Formula
C45H57NO14
Molecular Weight
835.932
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzenepropanoic acid, b-[[ (1,1-dimethylethoxy) carbonyl]amino]-a-hydroxy-, 12b- (acetyloxy) -12- (benzoyloxy) -2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-y

Alternative Products

CatalogName
B2157-50Cabazitaxel

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