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Cilofexor

CAT: 0013-GTR19163272-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19163272-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cilofexor (GS-9674, GS9674, PX-104) is a novel specific, non-steroidal farnesoid X receptor (FXR) agonist that reduces liver fibrosis and ameliorates portal hypertension in rat NASH models.Steatohepatitis, Phase 2 Clinical (In Vivo) :Cilofexor (GS-9674; 30 mg/kg; oral gavage; once daily; for 10 weeks; male Wistar rats) treatment significantly increases Fgf15 expression in the ileum and decreased Cyp7a1 in the liver in nonalcoholic steatohepatitis (NASH) rats. Liver fibrosis and hepatic collagen expression are significantly reduced. Cilofexor also significantly reduces hepatic stellate cell (HSC) activation and significantly decreases portal pressure, without affecting systemic hemodynamics.
CAS Number
1418274-28-8
Product Name Alternative
GS-9674 | GS9674 | PX-104
Purity
>98% (HPLC)
Solubility
DMSO : 125 mg/mL213.00 mM; H2O : < 0.1 mg/mL
Smiles
OC (C1=CC=NC (N2CC (O) (C2) C3=C (C=C (C=C3) OCC4=C (ON=C4C5=C (C=CC=C5Cl) Cl) C6CC6) Cl) =C1) =O
Molecular Formula
C28H22Cl3N3O5
Molecular Weight
586.85
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2-[3-[2-Chloro-4-[[5-cyclopropyl-3- (2,6-dichlorophenyl) -4-isoxazolyl]methoxy]phenyl]-3-hydroxy-1-azetidinyl]-4-pyridinecarboxylic acid

Alternative Products

CatalogName
BA3598-1Cilofexor
A13143-50Cilofexor 50mg
A13143-5Cilofexor 5mg
A13143-2Cilofexor 2mg
T69724-01Cilofexor tromethamine
A13143-25Cilofexor 25mg
HY-109083ACilofexor (tromethamine)
A13143-500Cilofexor 500mg
A13143-100Cilofexor 100mg
A13143-10Cilofexor 10mg

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