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Olmesartan

CAT: 0013-GTR19163199-02Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163199-02Size:25 mg
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Description
An angiotensin II receptor antagonist which has been used for the treatment of high blood pressure. Hypertension Discontinued (In Vitro) :Olmesartan (0.7-5 mM; 24, 48 and 72 h) inhibits the growth of HeLa cells as a concentration- and time-dependent mode. (In Vivo) :Repeated dosing of olmesartan (1 mg/kg, 2 mg/kg, p.o.) dose-dependently decreases mean arterial blood pressure (MAP) in SHR without significant influence on body weight and food intake during 10 weeks. Olmesartan (5 mg/kg/d, p.o.) and Hyd treatments lower systolic blood pressure to the same degree in mice. Olmesartan treatment inhibits cardiac hypertrophy, evaluated by echocardiography, heart weight, cross-sectional area of cardiomyocytes, and gene expression. Olmesartan treatment reverses decreased gene expressions of ACE2 and Mas receptor of Ren-Tg mice and inhibits enhanced NADPH oxidase (Nox) 4 expression and reactive oxygen species.
CAS Number
144689-24-7
Product Name Alternative
RNH 6270 | CS 088
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 55 mg/mL
Smiles
O=C (C1=C (C (C) (O) C) N=C (CCC) N1CC2=CC=C (C3=CC=CC=C3C4=NN=NN4) C=C2) O
Molecular Formula
C24H26N6O3
Molecular Weight
446.5016
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1H-Imidazole-5-carboxylic acid, 4- (1-hydroxy-1-methylethyl) -2-propyl-1-[[2'- (2H-tetrazol-5-yl) [1,1'-biphenyl]-4-yl]methyl]-

Chemical Information

Olmesartan

Olmesartan is a biphenylyltetrazole. It has a role as an antihypertensive agent and an angiotensin receptor antagonist.

CAS Number144689-24-7
PubChem CID158781
IUPAC Name5-(2-hydroxypropan-2-yl)-2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylic acid
Molecular FormulaC24H26N6O3
Molecular Weight446.5
XLogP3.2
Topological Polar Surface Area130
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count8
Heavy Atom Count33
Formal Charge0
Complexity656
SMILES
CCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)C(=O)O)C(C)(C)O
InChI
InChI=1S/C24H26N6O3/c1-4-7-19-25-21(24(2,3)33)20(23(31)32)30(19)14-15-10-12-16(13-11-15)17-8-5-6-9-18(17)22-26-28-29-27-22/h5-6,8-13,33H,4,7,14H2,1-3H3,(H,31,32)(H,26,27,28,29)
InChIKey
VTRAEEWXHOVJFV-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Olmesartan
CAS: 144689-24-7
CID: 158781
Formula: C24H26N6O3
MW: 446.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight446.5
XLogP33.2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count8
Exact Mass446.20663871
Monoisotopic Mass446.20663871
Topological Polar Surface Area130 Ų
Heavy Atom Count33
Formal Charge0
Complexity656
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
A3681-5.1Olmesartan
AR-O01214-01Olmesartan EP Impurity A (Olmesartan Acid)
CS-O-05965Olmesartan Acid
CS-EO-03087Nitroso Olmesartan
HY-17004S1Olmesartan-d6
O5975-01L-01Olmesartan Medoxomil
TRC-D229960-10MGDehydro Olmesartan

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