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Olmesartan

CAT: 0013-GTR19163199-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19163199-01Size:1 g
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Description
An angiotensin II receptor antagonist which has been used for the treatment of high blood pressure. Hypertension Discontinued (In Vitro) :Olmesartan (0.7-5 mM; 24, 48 and 72 h) inhibits the growth of HeLa cells as a concentration- and time-dependent mode. (In Vivo) :Repeated dosing of olmesartan (1 mg/kg, 2 mg/kg, p.o.) dose-dependently decreases mean arterial blood pressure (MAP) in SHR without significant influence on body weight and food intake during 10 weeks. Olmesartan (5 mg/kg/d, p.o.) and Hyd treatments lower systolic blood pressure to the same degree in mice. Olmesartan treatment inhibits cardiac hypertrophy, evaluated by echocardiography, heart weight, cross-sectional area of cardiomyocytes, and gene expression. Olmesartan treatment reverses decreased gene expressions of ACE2 and Mas receptor of Ren-Tg mice and inhibits enhanced NADPH oxidase (Nox) 4 expression and reactive oxygen species.
CAS Number
144689-24-7
Product Name Alternative
RNH 6270 | CS 088
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 55 mg/mL
Smiles
O=C (C1=C (C (C) (O) C) N=C (CCC) N1CC2=CC=C (C3=CC=CC=C3C4=NN=NN4) C=C2) O
Molecular Formula
C24H26N6O3
Molecular Weight
446.5016
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1H-Imidazole-5-carboxylic acid, 4- (1-hydroxy-1-methylethyl) -2-propyl-1-[[2'- (2H-tetrazol-5-yl) [1,1'-biphenyl]-4-yl]methyl]-

Alternative Products

CatalogName
A3681-5.1Olmesartan
AR-O01214-01Olmesartan EP Impurity A (Olmesartan Acid)
CS-O-05965Olmesartan Acid
CS-EO-03087Nitroso Olmesartan
HY-17004S1Olmesartan-d6
O5975-01L-01Olmesartan Medoxomil
TRC-D229960-10MGDehydro Olmesartan

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