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LY294002

CAT: 0013-GTR19163047-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163047-01Size:500 mg
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Description
A classic, broad-spectrum PI3K inhibitor with IC50 of 0.5/0.57/0.97 uM for PI3Kα/δ/β, respectively; completely and specifically abolishes PI3K activity (IC50=1.4 uM), but does not inhibit PI4K or other lipid kinases; demonstrates growth-inhibitory and apoptosis-inducing effect in colon cancer cell lines, with decreased phosphorylated Akt Ser (473) ; suppresses tumor growth in mouse xenografts; also is a potent inhibitor of CK2 with IC50 of 98 nM. (In Vitro) :LY294002 (0-75 μM; 24 hours and 48 hours) remarkably decreases human nasopharyngeal carcinoma CNE-2Z cells in a dose-dependent fashion.LY294002 (0-75 μM; 24 hours and 48 hours) induces CNE-2Z cells apoptosis rate in dose-dependent.LY294002 (10-75 μM) significantly decreases p-Akt (S473) expression levels and up-regulates caspase-9 activity in CNE-2Z cells. Total Akt protein level is not difference with different concentration.LY294002 (5, 10, 100 μM; for 2 hours) treatment partially suppresses Lysophosphatidic acid (LPA) -induced (20 μM; for 4 hours) nuclear translocation of YAP, accompanied by a reduction in p-AKT levels. (In Vivo) :LY294002 (10, 25, 50, 75 mg/kg; i.p.; twice weekly; for 4 weeks) significantly reduces mean NPC tumor burden in a dose-dependent manner. LY294002 (10, 25 mg/kg) is less effective in decreasing tumor burden.LY294002 (1.2 mg/kg per day; i.p.; for 14 days) prevents Leptin (60 ug/kg) -induced adverse effects on spermatozoa in Sprague-Dawley rats.
CAS Number
154447-36-6
Product Name Alternative
NSC 697286 | SF 1101 | LY 294002 | LY-294002
Purity
>98% (HPLC)
Solubility
DMSO: 14.9 mg/mL
Smiles
O=C1C=C (N2CCOCC2) OC3=C (C4=CC=CC=C4) C=CC=C13
Molecular Formula
C19H17NO3
Molecular Weight
307.3432
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4H-1-Benzopyran-4-one, 2- (4-morpholinyl) -8-phenyl-

Chemical Information

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one

LY294002 is a chromone substituted with a phenyl group at position 8 and a morpholine group at position 2. It has a role as a geroprotector, an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor and an autophagy inhibitor. It is a member of chromones, an organochlorine compound and a member of morpholines.

CAS Number154447-36-6
PubChem CID3973
IUPAC Name2-morpholin-4-yl-8-phenylchromen-4-one
Molecular FormulaC19H17NO3
Molecular Weight307.3
XLogP3.1
Topological Polar Surface Area38.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count23
Formal Charge0
Complexity463
SMILES
C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC=C4
InChI
InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2
InChIKey
CZQHHVNHHHRRDU-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
CAS: 154447-36-6
CID: 3973
Formula: C19H17NO3
MW: 307.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight307.3
XLogP33.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass307.12084340
Monoisotopic Mass307.12084340
Topological Polar Surface Area38.8 Ų
Heavy Atom Count23
Formal Charge0
Complexity463
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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