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Pancuronium bromide

CAT: 0013-GTR19163039-02Size: 5 mgDry Ice: NoHazardous: No
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Description
Pancuronium dibromide is a competitive AChR antagonist (IC50 = 5.5 nM) and acts as a skeletal muscle relaxant. Pancuronium dibromide interrupts neuromuscular transmission by competing with acetylcholine for receptor sites on the motor end-plate. (In Vitro) :The action of Pancuronium on transmembrane sodium conductance is investigated in dorsal root ganglion neurones of chick embryos. Externally perfused Pancuronium (50 μM to 1 mM) reversibly inhibits the current by a fast mechanism of action. Inhibition is concentration-dependent (with a half-effective dose of 170 μM) but not voltage-dependent. Pancuronium may reduce the sodium current by interacting with the sodium channels in both the resting and open states. (In Vivo) :Pancuronium (0.5 mg/kg; intravenous injection) abolishes the bradycardia induced both by injected acetylcholine (ACh) and by vagal nerve stimulation in guinea-pigs (250-300 g, male) . At doses which produce 100% neuromuscular blockade, Pancuronium (0.04 mg/kg) potentiates vagally-induced bronchoconstriction.Potentiation by Pancuronium of the effects of adrenergic nerve stimulation, is found in rat anococcygeus and vas deferens.
CAS Number
15500-66-0
Product Name Alternative
NSC 293162
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Very soluble in water
Smiles
CC (=O) O[C@H]1C[C@@H]2CC[C@@H]3[C@@H] ([C@]2 (C[C@@H]1[N+]4 (CCCCC4) C) C) CC[C@]5 ([C@H]3C[C@@H] ([C@@H]5OC (=O) C) [N+]6 (CCCCC6) C) C.[Br-].[Br-]
Molecular Formula
C35H60Br2N2O4
Molecular Weight
732.67
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Chemical Information

Pancuronium Bromide

Pancuronium bromide is a bromide salt consisting of two bromide ions and one pancuronium dication. It has a role as a cholinergic antagonist, a nicotinic antagonist and a muscle relaxant. It contains a pancuronium.

CAS Number15500-66-0
PubChem CID27350
IUPAC Name[(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-17-acetyloxy-10,13-dimethyl-2,16-bis(1-methylpiperidin-1-ium-1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate dibromide
Molecular FormulaC35H60Br2N2O4
Molecular Weight732.7
Topological Polar Surface Area52.6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Heavy Atom Count43
Formal Charge0
Complexity1000
SMILES
CC(=O)O[C@H]1C[C@@H]2CC[C@@H]3[C@@H]([C@]2(C[C@@H]1[N+]4(CCCCC4)C)C)CC[C@]5([C@H]3C[C@@H]([C@@H]5OC(=O)C)[N+]6(CCCCC6)C)C.[Br-].[Br-]
InChI
InChI=1S/C35H60N2O4.2BrH/c1-24(38)40-32-21-26-13-14-27-28(35(26,4)23-31(32)37(6)19-11-8-12-20-37)15-16-34(3)29(27)22-30(33(34)41-25(2)39)36(5)17-9-7-10-18-36;;/h26-33H,7-23H2,1-6H3;2*1H/q+2;;/p-2/t26-,27+,28-,29-,30-,31-,32-,33-,34-,35-;;/m0../s1
InChIKey
NPIJXCQZLFKBMV-YTGGZNJNSA-L
Chemical Structure
2D Structure
2D structure of Pancuronium Bromide
CAS: 15500-66-0
CID: 27350
Formula: C35H60Br2N2O4
MW: 732.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight732.7
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass732.28993
Monoisotopic Mass730.29198
Topological Polar Surface Area52.6 Ų
Heavy Atom Count43
Formal Charge0
Complexity1000
Isotope Atom Count0
Defined Atom Stereocenter Count10
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count3
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
328501Pancuronium Bromide
T37702-01Pancuronium (bromide hydrate)
AR-D06271-01Pancuronium Bromide EP Impurity C (Pancuronium Bromide USP Related Compound A)
RM-P140301-01Pancuronium Bromide EP Impurity A
AR-D06268-01Dacuronium Dibromide (Pancuronium Bromide EP Impurity A, Pancuronium Bromide USP Related Compound C)
RBA26171-01Pancuronium bromide related compound B
RM-P140302-01Pancuronium Bromide EP Impurity B
RM-V050300-01Vecuronium Bromide; Pancuronium Bromide EP Impurity D
RM-V050302-01Vecuronium Bromide EP Impurity B; Pancuronium bromide
RM-P140303-01Pancuronium Bromide EP Impurity C

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