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ARN-3236

CAT: 0013-GTR19162980-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19162980-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ARN-3236 is a novel potent, selective, and orally active SIK2 inhibitor with IC50 of <1 nM; does not significantly inhibit SIK1 and SIK3, as well as other AMPK family members; inhibits the growth of 10 ovarian cancer cell lines with IC50 of 0.8-2.6 uM; increasess centrosome uncoupling from nucleus, and inhibits centrosome splitting in mitotic cells; induces cell cycle arrest, apoptosis and tetraploidy, also inhibits AKT phosphorylation and attenuates survivin expression; sensitizes ovarian cancer to paclitaxel in SKOv3ip xenograft model.
CAS Number
1613710-01-2
Product Name Alternative
ARN3236
Purity
>98% (HPLC)
Solubility
DMSO : 130 mg/mL. 386.43 mM
Smiles
COC1=CC=C (C2=CNC3=NC=CC (C4=CSC=C4) =C32) C (OC) =C1
Molecular Formula
C19H16N2O2S
Molecular Weight
336.409
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
3- (2,4-Dimethoxyphenyl) -4- (3-thienyl) -1H-pyrrolo[2,3-b]pyridine

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Alternative Products

CatalogName
A4680-10ARN-3236
7511/50ARN 3236
A18725-500ARN-3236 500mg
A18725-1ARN-3236 1mg
A18725-10ARN-3236 10mg
A18725-2ARN-3236 2mg
A18725-200ARN-3236 200mg
A18725-100ARN-3236 100mg
A18725-50ARN-3236 50mg
A18725-25ARN-3236 25mg

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