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ARN-3236

CAT: 0013-GTR19162980-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19162980-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ARN-3236 is a novel potent, selective, and orally active SIK2 inhibitor with IC50 of <1 nM; does not significantly inhibit SIK1 and SIK3, as well as other AMPK family members; inhibits the growth of 10 ovarian cancer cell lines with IC50 of 0.8-2.6 uM; increasess centrosome uncoupling from nucleus, and inhibits centrosome splitting in mitotic cells; induces cell cycle arrest, apoptosis and tetraploidy, also inhibits AKT phosphorylation and attenuates survivin expression; sensitizes ovarian cancer to paclitaxel in SKOv3ip xenograft model.
CAS Number
1613710-01-2
Product Name Alternative
ARN3236
Purity
>98% (HPLC)
Solubility
DMSO : 130 mg/mL. 386.43 mM
Smiles
COC1=CC=C (C2=CNC3=NC=CC (C4=CSC=C4) =C32) C (OC) =C1
Molecular Formula
C19H16N2O2S
Molecular Weight
336.409
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
3- (2,4-Dimethoxyphenyl) -4- (3-thienyl) -1H-pyrrolo[2,3-b]pyridine

Chemical Information

3-(2,4-dimethoxyphenyl)-4-(thiophen-3-yl)-1H-pyrrolo[2,3-b]pyridine
CAS Number1613710-01-2
PubChem CID74766530
IUPAC Name3-(2,4-dimethoxyphenyl)-4-thiophen-3-yl-1H-pyrrolo[2,3-b]pyridine
Molecular FormulaC19H16N2O2S
Molecular Weight336.4
XLogP4.2
Topological Polar Surface Area75.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Heavy Atom Count24
Formal Charge0
Complexity424
SMILES
COC1=CC(=C(C=C1)C2=CNC3=NC=CC(=C23)C4=CSC=C4)OC
InChI
InChI=1S/C19H16N2O2S/c1-22-13-3-4-15(17(9-13)23-2)16-10-21-19-18(16)14(5-7-20-19)12-6-8-24-11-12/h3-11H,1-2H3,(H,20,21)
InChIKey
WEHOIIGXTMKVRG-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 3-(2,4-dimethoxyphenyl)-4-(thiophen-3-yl)-1H-pyrrolo[2,3-b]pyridine
CAS: 1613710-01-2
CID: 74766530
Formula: C19H16N2O2S
MW: 336.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight336.4
XLogP34.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass336.09324893
Monoisotopic Mass336.09324893
Topological Polar Surface Area75.4 Ų
Heavy Atom Count24
Formal Charge0
Complexity424
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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A4680-10ARN-3236
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