CC-671

CAT: 0013-GTR19162965-01Size: 1 gDry Ice: NoHazardous: No

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CAT#:0013-GTR19162965-01Size:1 g

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

CC-671 is a potent, selective, dual TTK (Mps1) /CLK2 inhibitor with IC50 of 5/3 nM, respectively; weakly inhibits DYRK3, DYRK1A, PHKG, DYRK1B, and CLK1 with IC50 of 0.1-0.3 uM, and displays excellent kinase selectivity (7/235 kinases > 80% inhibition at 3 uM) ; inhibits autophosphorylation of TTK at T686 or phosphorylation of SR protein 75 with IC50 of 0.057 and 0.549 uM in Cal-51 cells; demonstrates strong single agent in vivo efficacy in multiple TNBC xenograft models without significant body weight loss.Breast Cancer Preclinical.

CAS Number

1618658-88-0

Product Name Alternative

CC671 | CC 671

Purity

>98% (HPLC)

Solubility

DMSO: 60 mg/mL (< 1 mg/ml refers to the product slightly soluble or insoluble)

Smiles

O=C (NC) C1=CC=C (NC2=NC (OC3CCCC3) =C4C (NC=C4C5=CC=C6N=C (C) OC6=C5) =N2) C (OC) =C1

Molecular Formula

C28H28N6O4

Molecular Weight

512.57

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

4- ((4- (cyclopentyloxy) -5- (2-methylbenzo[d]oxazol-6-yl) -7H-pyrrolo-[2,3-d]pyrimidin-2-yl) amino) -3-methoxy-N-methylbenzamide

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Alternative Products

Catalog	Name
BA3793-25	CC-671
A16995-50	CC-671 50mg
A16995-25	CC-671 25mg
A16995-10	CC-671 10mg
A16995-5	CC-671 5mg
A16995-500	CC-671 500mg
A16995-100	CC-671 100mg
A16995-1	CC-671 1mg
A16995-10mM-D	CC-671 10mM * 1mL in DMSO
BF166966-01	FT 671

CC-671

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