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FL-411

CAT: 0013-GTR19162787-04Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19162787-04Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FL-411 is a novel small-molecule inhibitor of BRD4, induces ATG5-dependent autophagy-associated cell death (ACD) by blocking BRD4-AMPK interaction and activating AMPK-mTOR-ULK1-modulated autophagic pathway in breast cancer cells; induces ACD pathways involved in HMGB1, VDAC1/2, and eEF2, displays a therapeutic potential on both breast cancer xenograft mouse and zebrafish models.
CAS Number
2118944-88-8
Product Name Alternative
FL411
Purity
>98% (HPLC)
Solubility
< 1 mg/ml refers to the product slightly soluble or insoluble
Smiles
CC1=CC (=CC (=C1O) C) C2=NC3=C (C4=C (S3) CN (CC4) C) C (=O) N2
Molecular Formula
C18H19N3O2S
Molecular Weight
341.429
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2- (4-Hydroxy-3,5-dimethylphenyl) -7-methyl-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4 (3H) -one

Chemical Information

2-(4-Hydroxy-3,5-Dimethylphenyl)-7-Methyl-5,6,7,8-Tetrahydropyrido[4',3':4,5]thieno[2,3-D]pyrimidin-4(3h)-One
CAS Number2118944-88-8
PubChem CID135567026
IUPAC Name5-(4-hydroxy-3,5-dimethylphenyl)-11-methyl-8-thia-4,6,11-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),5-trien-3-one
Molecular FormulaC18H19N3O2S
Molecular Weight341.4
XLogP2.6
Topological Polar Surface Area93.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count1
Heavy Atom Count24
Formal Charge0
Complexity542
SMILES
CC1=CC(=CC(=C1O)C)C2=NC3=C(C4=C(S3)CN(CC4)C)C(=O)N2
InChI
InChI=1S/C18H19N3O2S/c1-9-6-11(7-10(2)15(9)22)16-19-17(23)14-12-4-5-21(3)8-13(12)24-18(14)20-16/h6-7,22H,4-5,8H2,1-3H3,(H,19,20,23)
InChIKey
PXJZRFLBUBYEPV-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-(4-Hydroxy-3,5-Dimethylphenyl)-7-Methyl-5,6,7,8-Tetrahydropyrido[4',3':4,5]thieno[2,3-D]pyrimidin-4(3h)-One
CAS: 2118944-88-8
CID: 135567026
Formula: C18H19N3O2S
MW: 341.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight341.4
XLogP32.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count1
Exact Mass341.11979803
Monoisotopic Mass341.11979803
Topological Polar Surface Area93.2 Ų
Heavy Atom Count24
Formal Charge0
Complexity542
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
HY-111102-01FL-411
TJD94488-01FL 411
A19506-25FL-411 25mg
A19506-2FL-411 2mg
A19506-50FL-411 50mg
A19506-5FL-411 5mg
A19506-200FL-411 200mg
A19506-100FL-411 100mg
A19506-10FL-411 10mg
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