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HS-1371

CAT: 0013-GTR19162761-06Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19162761-06Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HS-1371 (HS1371) is a novel potent, ATP-competitive receptor-interacting protein kinase-3 (RIP3 or RIPK3 kinase) inhibitor with IC50 of 20.8 nM; binds to the ATP binding pocket of RIP3 and inhibits ATP binding to prevent RIP3 enzymatic activity in vitro; inhibits S227 auto-phosphorylation of RIP3 in treated HT-29 cells, blocks necrosome complex formation, rescues cells from RIP3-dependent necroptotic cell death but not apoptotic cell death.
CAS Number
2158197-70-5
Product Name Alternative
HS1371 | HS 1371
Purity
>98% (HPLC)
Solubility
DMSO : 16.67 mg/mL 43.36 mM
Smiles
CC1=CC=C (OC2=CC=NC3=CC (C4=CN (C5CCNCC5) N=C4) =CC=C23) C=C1
Molecular Formula
C24H24N4O
Molecular Weight
384.483
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
7- (1- (Piperidin-4-yl) -1H-pyrazol-4-yl) -4- (p-tolyloxy) quinoline

Chemical Information

7-(1-(Piperidin-4-yl)-1h-pyrazol-4-yl)-4-(p-tolyloxy)quinoline
CAS Number2158197-70-5
PubChem CID134817449
IUPAC Name4-(4-methylphenoxy)-7-(1-piperidin-4-ylpyrazol-4-yl)quinoline
Molecular FormulaC24H24N4O
Molecular Weight384.5
XLogP4
Topological Polar Surface Area52
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Heavy Atom Count29
Formal Charge0
Complexity517
SMILES
CC1=CC=C(C=C1)OC2=C3C=CC(=CC3=NC=C2)C4=CN(N=C4)C5CCNCC5
InChI
InChI=1S/C24H24N4O/c1-17-2-5-21(6-3-17)29-24-10-13-26-23-14-18(4-7-22(23)24)19-15-27-28(16-19)20-8-11-25-12-9-20/h2-7,10,13-16,20,25H,8-9,11-12H2,1H3
InChIKey
VPVLPCIBKVWFDT-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 7-(1-(Piperidin-4-yl)-1h-pyrazol-4-yl)-4-(p-tolyloxy)quinoline
CAS: 2158197-70-5
CID: 134817449
Formula: C24H24N4O
MW: 384.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight384.5
XLogP34
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass384.19501140
Monoisotopic Mass384.19501140
Topological Polar Surface Area52 Ų
Heavy Atom Count29
Formal Charge0
Complexity517
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
BA3498-100HS-1371
A18653-100HS-1371 100mg
A18653-50HS-1371 50mg
A18653-10HS-1371 10mg
A18653-5HS-1371 5mg
A18653-25HS-1371 25mg
A18653-1HS-1371 1mg
A18653-10mM-DHS-1371 10mM * 1mL in DMSO
BH300142HS-1371 - Bio-X TM

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