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HS-1371

CAT: 0013-GTR19162761-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19162761-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HS-1371 (HS1371) is a novel potent, ATP-competitive receptor-interacting protein kinase-3 (RIP3 or RIPK3 kinase) inhibitor with IC50 of 20.8 nM; binds to the ATP binding pocket of RIP3 and inhibits ATP binding to prevent RIP3 enzymatic activity in vitro; inhibits S227 auto-phosphorylation of RIP3 in treated HT-29 cells, blocks necrosome complex formation, rescues cells from RIP3-dependent necroptotic cell death but not apoptotic cell death.
CAS Number
2158197-70-5
Product Name Alternative
HS1371 | HS 1371
Purity
>98% (HPLC)
Solubility
DMSO : 16.67 mg/mL 43.36 mM
Smiles
CC1=CC=C (OC2=CC=NC3=CC (C4=CN (C5CCNCC5) N=C4) =CC=C23) C=C1
Molecular Formula
C24H24N4O
Molecular Weight
384.483
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
7- (1- (Piperidin-4-yl) -1H-pyrazol-4-yl) -4- (p-tolyloxy) quinoline

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Alternative Products

CatalogName
BA3498-100HS-1371
A18653-5HS-1371 5mg
A18653-100HS-1371 100mg
A18653-50HS-1371 50mg
A18653-10HS-1371 10mg
A18653-25HS-1371 25mg
A18653-1HS-1371 1mg
A18653-10mM-DHS-1371 10mM * 1mL in DMSO
BH300142HS-1371 - Bio-X TM

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