Fludarabine

CAT: 0013-GTR19162755-01Size: 500 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19162755-01Size:500 mg

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Description

Fludarabine (NSC 118218), a DNA synthesis inhibitor, is a chemotherapy drug used in the treatment of hematological malignancies. (In Vitro) :Fludarabine (5 μM; 48 hours) induces a decrease in p27kip1 expression. (In Vivo) :Fludarabine (0.8 mg/kg; i.p.; two cycles for 5 days every 2 weeks) in combination with Cyclophosphamide (400 mg/kg; i.p.; 2 weeks) decreases incidence of GVHD.

CAS Number

21679-14-1

Product Name Alternative

F-ara-A | NSC 118218

Purity

>98% (HPLC)

Solubility

DMSO: 57 mg/mL (199.83 mM)

Smiles

NC1=C2N=CN ([C@H]3[C@H] ([C@@H] ([C@@H] (CO) O3) O) O) C2=NC (F) =N1

Molecular Formula

C10H12FN5O4

Molecular Weight

285.23

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

(2R,3S,4S,5R) -2- (6-amino-2-fluoro-9H-purin-9-yl) -5- (hydroxymethyl) tetrahydrofuran-3,4-diol

Chemical Information

Fludarabine

(2R,3S,4S,5R)-2-(6-amino-2-fluoro-9-purinyl)-5-(hydroxymethyl)oxolane-3,4-diol is a purine nucleoside.

CAS Number	21679-14-1
PubChem CID	657237
IUPAC Name	(2R,3S,4S,5R)-2-(6-amino-2-fluoropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
Molecular Formula	C10H12FN5O4
Molecular Weight	285.23
XLogP	-0.6
Topological Polar Surface Area	140
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	2
Heavy Atom Count	20
Formal Charge	0
Complexity	367

SMILES

C1=NC2=C(N=C(N=C2N1[C@H]3[C@H]([C@@H]([C@H](O3)CO)O)O)F)N

InChI

InChI=1S/C10H12FN5O4/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,14,15)/t3-,5-,6+,9-/m1/s1

InChIKey

HBUBKKRHXORPQB-FJFJXFQQSA-N

Chemical Structure

2D Structure

CAS: 21679-14-1

CID: 657237

Formula: C10H12FN5O4

MW: 285.23

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	285.23
XLogP3	-0.6
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	2
Exact Mass	285.08733204
Monoisotopic Mass	285.08733204
Topological Polar Surface Area	140 Å²
Heavy Atom Count	20
Formal Charge	0
Complexity	367
Isotope Atom Count	0
Defined Atom Stereocenter Count	4
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
T1038-01	Fludarabine

Fludarabine

Chemical Information

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