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BIBR 1532

CAT: 0013-GTR19162598-05Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19162598-05Size:50 mg
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Description
BIBR 1532 is a potent, selective, non-competitive telomerase inhibitor with IC50 of 100 nM in a cell-free assay. (In Vitro) :BIBR 1532 non-competitively inhibits telomerase activity. BIBR 1532 inhibits the proliferation of JVM13 leukemia cells with an IC50 of 52 μM, and similar effect also occurs in other leukemia cell lines such as Nalm-1, HL-60, and Jurkat. BIBR 1532 exerts antiproliferative effect on acute myeloid leukemia (AML) with IC50 of 56 μM with no effect on the proliferative capacity of normal hematopoietic progenitor cells. BIBR 1532 (2.5 μM) reduces colony-forming ability, induces telomere length shortening and causes chemotherapeutic sensitization via inhibiting telomerase activity in MCF-7/WT and melphalan-resistant MCF-7/MlnR cell lines. BIBR 1532 is cytotoxic in a dose-dependent manner in T-cell prolymphocytic leukemia (T-PLL) . BIBR 1532 in combination with carboplatin (a chemotherapeutic agent) eliminates ovarian cancer spheroid-forming cells in ES2, SKOV3, and TOV112D cell lines.
CAS Number
321674-73-1
Product Name Alternative
Telomerase Inhibitor X
Purity
>98% (HPLC)
Solubility
Ethanol: 3 mg/mL (9.05 mM) ; DMSO: 66 mg/mL (199.17 mM)
Smiles
O=C (O) C1=CC=CC=C1NC (/C=C (C2=CC=C3C=CC=CC3=C2) \C) =O
Molecular Formula
C21H17NO3
Molecular Weight
331.36
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(E) -2- (3- (naphthalen-2-yl) but-2-enamido) benzoic acid

Chemical Information

Bibr 1532

2-[[3-(2-naphthalenyl)-1-oxobut-2-enyl]amino]benzoic acid is an amidobenzoic acid.

CAS Number321674-73-1
PubChem CID9927531
IUPAC Name2-[[(E)-3-naphthalen-2-ylbut-2-enoyl]amino]benzoic acid
Molecular FormulaC21H17NO3
Molecular Weight331.4
XLogP5.1
Topological Polar Surface Area66.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Heavy Atom Count25
Formal Charge0
Complexity527
SMILES
C/C(=C\C(=O)NC1=CC=CC=C1C(=O)O)/C2=CC3=CC=CC=C3C=C2
InChI
InChI=1S/C21H17NO3/c1-14(16-11-10-15-6-2-3-7-17(15)13-16)12-20(23)22-19-9-5-4-8-18(19)21(24)25/h2-13H,1H3,(H,22,23)(H,24,25)/b14-12+
InChIKey
PGFQXGLPJUCTOI-WYMLVPIESA-N
Chemical Structure
2D Structure
2D structure of Bibr 1532
CAS: 321674-73-1
CID: 9927531
Formula: C21H17NO3
MW: 331.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight331.4
XLogP35.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass331.12084340
Monoisotopic Mass331.12084340
Topological Polar Surface Area66.4 Ų
Heavy Atom Count25
Formal Charge0
Complexity527
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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