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BIBO 3304

CAT: 0013-GTR19217375-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19217375-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BIBO 3304 is a potent, selective, nonpeptide neuropeptide Y Y1 receptor antagonist with IC50 of 0.38 and 0.72 nM for human and the rat Y1 receptor, respectively; shows low affinity for the human Y2 receptor, human and rat Y4 receptor, human and rat Y5 receptor (IC50>1,000 nM) ; inhibits the feeding response induced by 1 mg NPY in mice, also completely abolishes PYY-induced inhibition of insulin release in vivo.Obesity Discontinued (In Vivo) :BIBO3304 TFA (30 μg; bilateral paraventricular nucleus injection) attenuates the hyperphagia following fasting.BIBO3304 TFA (15-60 μg) dose-dependently inhibits the feeding reponse mediated by 1 μg NPY.BIBO3304 TFA (0.5 μM; p.o.) significantly increases serum insulin levels.
CAS Number
191868-14-1
Product Name Alternative
BIBO3304
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (155.36 mM)
Smiles
C1=CC=C (C=C1) C (C2=CC=CC=C2) C (=O) NC (CCCN=C (N) N) C (=O) NCC3=CC=C (C=C3) CNC (=O) N
Molecular Formula
C31H36F3N7O5
Molecular Weight
643.668
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(R) -2- (2,2-diphenylacetamido) -5-guanidino-N- (4- (ureidomethyl) benzyl) pentanamide 2,2,2-trifluoroacetate

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