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Avanafil

CAT: 0013-GTR19162571-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19162571-01Size:1 g
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Description
A potent and highly selective PDE5 inhibitor (IC50=5.2 nM) for erectile dysfunction; shows no significant effect on PDE1, PDE6 and PDE11.Sexual Dysfunction Approved (In Vitro) :Avanafil (TA-1790) (0.01-1000 μM) enhances by 45% for electrical field stimulation (1-20 Hz) -induced relaxation responses in corpus cavernosum strips from the diabetic group. (In Vivo) :Avanafil (TA-1790) (10 mg/kg; p.o.; daily, for 30 d; male rat) increases angiogenesis in bone tissue via the activation of NO, cGMP and PKG (NO/cGMP/PKG) signaling-pathway and significantly decreases dexamethasone-induced loss in BMD, bone atrophy, and oxidative stress.Avanafil (TA-1790) (10 μM; ICI; once, for 10 weeks) improves erectile responses in T2DM rats.
CAS Number
330784-47-9
Product Name Alternative
TA1790 | TA 1790 | TA-1790
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=C (C1=CN=C (N2[C@H] (CO) CCC2) N=C1NCC3=CC=C (OC) C (Cl) =C3) NCC4=NC=CC=N4
Molecular Formula
C23H26ClN7O3
Molecular Weight
483.9507
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
5-Pyrimidinecarboxamide, 4-[[ (3-chloro-4-methoxyphenyl) methyl]amino]-2-[ (2S) -2- (hydroxymethyl) -1-pyrrolidinyl]-N- (2-pyrimidinylmethyl) -

Alternative Products

CatalogName
002976Avanafil

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