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Mdivi 1

CAT: 0013-GTR19163512-07Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163512-07Size:100 mg
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Description
Mdivi-1 is a selective cell-permeable inhibitor of mitochondrial division DRP1 (dynamin-related GTPase) and mitochondrial division Dynamin I (Dnm1) with IC50 of 1-10 μM. (In Vitro) :Mdivi-1 inhibits Dnm1 GTPase activity in a dose-dependent manner, with an estimated EC50 of 1-10 μM. Mdivi-1 increases the apparent K0.5 for GTP, lowers the apparent Vmax for GTP hydrolysis, and causes an increase in the Hill coefficient observed for GTP in the Dnm1 GTP hydrolysis reaction. Cells treated with mdivi-1 display decreased cytochrome c release and a reduced rate of phosphatidylserine exposure on their surface following apoptosis induction, consistent with an inhibition of apoptosis and with previous studies using other strategies to compromise DRP1 activity. Mdivi-1 results in apoptotic cell death in ischemic retina. (In Vivo) :The mitochondrial division DRP, Dnm1, is the target of mdivi-1 in vivo. Mdivi-1 quantitatively blocks GMPPCP- dependent Dnm1 self-assembly in a concentration range similar to its effects on mitochondrial division in vivo. Mdivi-1 (50 mg/kg, i.p.) significantly decreases GFAP protein expression in the normal mouse retina.
CAS Number
338967-87-6
Product Name Alternative
Mitochondrial Division Inhibitor 1
Purity
>98% (HPLC)
Solubility
DMSO: 70 mg/mL (198.17 mM)
Smiles
O=C1N (C2=CC (OC) =C (Cl) C=C2Cl) C (NC3=C1C=CC=C3) =S
Molecular Formula
C15H10Cl2N2O2S
Molecular Weight
353.22
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
3- (2,4-dichloro-5-methoxyphenyl) -2-thioxo-2,3-dihydroquinazolin-4 (1H) -one

Chemical Information

3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone

Mdivi-1 is a member of quinazolines.

CAS Number338967-87-6
PubChem CID3825829
IUPAC Name3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanylidene-1H-quinazolin-4-one
Molecular FormulaC15H10Cl2N2O2S
Molecular Weight353.2
XLogP4
Topological Polar Surface Area73.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Heavy Atom Count22
Formal Charge0
Complexity465
SMILES
COC1=C(C=C(C(=C1)N2C(=O)C3=CC=CC=C3NC2=S)Cl)Cl
InChI
InChI=1S/C15H10Cl2N2O2S/c1-21-13-7-12(9(16)6-10(13)17)19-14(20)8-4-2-3-5-11(8)18-15(19)22/h2-7H,1H3,(H,18,22)
InChIKey
NZJKEVWTYMOYOR-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone
CAS: 338967-87-6
CID: 3825829
Formula: C15H10Cl2N2O2S
MW: 353.2
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight353.2
XLogP34
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Exact Mass351.9840041
Monoisotopic Mass351.9840041
Topological Polar Surface Area73.7 Ų
Heavy Atom Count22
Formal Charge0
Complexity465
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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