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INO-1001

CAT: 0013-GTR19162395-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19162395-01Size:1 g
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Description
INO-1001 is a potent, selective poly (ADP-ribose) polymerase (PARP) with IC50 of 1 μM) causes more than 95% inhibition of PARP activity without significant cellular toxicity. INO-1001 significantly sensitizes CHO cells by blocking most of the DNA repair occurring between radiation fractions. 3-Aminobenzamide significantly improves endothelial function by enhancing the acetylcholine-induced, endothelium-dependent, nitric oxide mediated vasorelaxation after exposure with 400 μM H2O2. (In Vivo) :In a db/db (Leprdb/db) mouse model, 3-Aminobenzamide ameliorates diabetes-induced albumin excretion and mesangial expansion, and also decreases diabetes-induced podocyte depletion. 3-Aminobenzamide (1.6 mg/kg via intracerebral injection) prevents NAD+ depletion and improves water maze performance after controlled cortical impact (CCI) in mice.
CAS Number
3544-24-9
Product Name Alternative
3-Aminobenzamide | INO1001 | INO 1001
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
NC (=O) C1=CC (N) =CC=C1
Molecular Formula
C7H8N2O
Molecular Weight
136.1512
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzamide, 3-amino-

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B8462-50INO-1001
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