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FCCP

CAT: 0013-GTR19162344-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19162344-01Size:1 g
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Description
FCCP is a potent uncoupler of oxidative phosphorylation in mitochondria that disrupts ATP synthesis by transporting protons across cell membranes. (In Vitro) :FCCP (5 μM) results in a concentration-dependent decrease in Aβ and APPsβ production in K695sw cells. FCCP inhibits processing of wild-type APP. FCCP does not alter cellular ATP levels at any of the concentrations measured. The effects of FCCP on APP catabolism are independent of secondary effects on oxidative phosphorylation or the result of reduced cell viability in K695sw cells. FCCP (5 μM or 500 nM), baf A1, and NH4Cl induce changes in Tf-Tx and Tf-F cellular fluorescence in K695 cells. FCCP (200 nM) protects and enhances the follicle integrity in cat ovarian tissue during short-term in vitro culture. But FCCP does not appear to exert a beneficial or detrimental effect during ovarian tissue cryopreservation.
CAS Number
370-86-5
Product Name Alternative
Trifluoromethoxy carbonylcyanide phenylhydrazone
Purity
>98% (HPLC)
Solubility
Ethanol: 50 mg/mL (196.71 mM) DMSO: 50 mg/mL (196.71 mM) Water: <1 mg/mL
Smiles
N#C/C (C#N) =N/NC1=CC=C (OC (F) (F) F) C=C1
Molecular Formula
C10H5F3N4O
Molecular Weight
254.17
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N- (4- (trifluoromethoxy) phenyl) carbonohydrazonoyl dicyanide

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