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NSC 185058

CAT: 0013-GTR19162292-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19162292-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NSC 185058 (NSC185058, NSC-185058, 2-Pyridinecarbothioamide) is a novel ATG4B antagonist that inhibits autophagy with IC50 of 50 uM, with no effect on mTOR and PI3K activities; directly inhibits cellular ATG4B activity induced by starvation or rapamycin and suppresses the lipidation of LC3B and autophagosome formation in response to starvation, suppresses Saos-2 osteosarcoma growth in vivo; markedly slows tumor growth and provides a significant survival benefit in GBM xenografts combined with radiotherapy.
CAS Number
39122-38-8
Product Name Alternative
NSC185058 | NSC-185058 | 2-Pyridinecarbothioamide
Field of Research
Neuroscience
Purity
>98% (HPLC)
Solubility
DMSO: 30 mg/mL, 139.36 mME; thanol: 2.5 mg/mL (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
S=C (C1=NC=CC=C1) NC2=NC=CC=C2
Molecular Formula
C11H9N3S
Molecular Weight
215.274
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N-pyridin-2-ylpyridine-2-carbothioamide

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PBA12238-01NSC 185058
A17121-100NSC 185058 100mg
A17121-10NSC 185058 10mg
A17121-1NSC 185058 1mg
A17121-25NSC 185058 25mg
A17121-50NSC 185058 50mg
A17121-5NSC 185058 5mg

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