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Flumequine

CAT: 0013-GTR19162228-03Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19162228-03Size:50 mg
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Description
Flumequine is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class used to treat bacterial infections. (In Vitro) :Flumequine (R-802) is a topoisomerase II inhibitor, with an IC50 of 3.92 μg/mL, and less potently inhibits Gyrase, with an IC50 of 1764 μg/mL. Flumequine (0-625 μg/mL) increases migration of nuclear DNA from CHL cells. Flumequine (R-802) inhibits Spanish field isolates of B. hyodysenteriae with MIC50 and MIC90 of 50 and 100 μg/mL, and MBC50 and MBC90 of 50, 200 μg/mL, respectively. Flumequine (R-802) suppresses A. salmonicida isolates with MIC ranging from 0.06 to 32 μg/mL. (In Vivo) :Flumequine (R-802) (0-500 mg/kg, p.o.) causes dose-related DNA damage in the stomach, colon, and urinary bladder of mice, 1 and 3 h but not 24 h after its administration.
CAS Number
42835-25-6
Product Name Alternative
(±) -Flumequine
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO: 3 mg/mL (11.48 mM)
Smiles
O=C (C (C1=O) =CN2C (C) CCC3=C2C1=CC (F) =C3) O
Molecular Formula
C14H12FNO3
Molecular Weight
261.25
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
7-Fluoro-12-methyl-4-oxo-1-azatricyclo[7.3.1.05,13]trideca-2,5,7,9 (13) -tetraene-3-carboxylic acid

Chemical Information

Flumequine

9-fluoro-5-methyl-1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid is a member of the class of pyridoquinolines that is 1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline carrying additional carboxy, methyl and fluoro substituents at positions 2, 5 and 9 respectively. It is an organofluorine compound, a pyridoquinoline, a 3-oxo monocarboxylic acid and a quinolone antibiotic.

CAS Number42835-25-6
PubChem CID3374
IUPAC Name7-fluoro-12-methyl-4-oxo-1-azatricyclo[7.3.1.05,13]trideca-2,5,7,9(13)-tetraene-3-carboxylic acid
Molecular FormulaC14H12FNO3
Molecular Weight261.25
XLogP2.9
Topological Polar Surface Area57.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count1
Heavy Atom Count19
Formal Charge0
Complexity462
SMILES
CC1CCC2=C3N1C=C(C(=O)C3=CC(=C2)F)C(=O)O
InChI
InChI=1S/C14H12FNO3/c1-7-2-3-8-4-9(15)5-10-12(8)16(7)6-11(13(10)17)14(18)19/h4-7H,2-3H2,1H3,(H,18,19)
InChIKey
DPSPPJIUMHPXMA-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Flumequine
CAS: 42835-25-6
CID: 3374
Formula: C14H12FNO3
MW: 261.25
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight261.25
XLogP32.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count1
Exact Mass261.08012141
Monoisotopic Mass261.08012141
Topological Polar Surface Area57.6 Ų
Heavy Atom Count19
Formal Charge0
Complexity462
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
FF23327-01Flumequine

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