Products for Research Use Only
RegisterLogin

Nabumetone

CAT: 0013-GTR19162226-01Size: 500 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19162226-01Size:500 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Nabumetone (BRL14777) is a non-steroidal anti-inflammatory drug and its active metabolite inhibits the COX. (In Vitro) :Nabumetone is a potent and selective COX-2 inhibitor. Nabumetone (50 μmol-2 mmol) dose-dependently inhibits the proliferation of K-562 and Meg-01 cells, but shows no obvious apoptotic effect. Nabumetone potentiates the apoptotic effect of ADR in the K-562 cell line. Moreover, Nabumetone reduces Bcl-2 expression. (In Vivo) :Nabumetone (79 mg/kg, p.o.) inhibits paw oedema and paw exudate PGE2 in rats. Nabumetone does not induce gastric damage and causes only 57% inhibition of gastric mucosal 6-keto-PGF1α production in rats. Nabumetone (25, 50, 100 mg/kg, i.p.) dose-dependently inhibits the increase of DDC-induced mucus secretion and stimulates stress-induced mucus secretion in rats. Nabumetone (25 mg/kg, i.p.) significantly suppresses stress-induced ulcer index in rats.
CAS Number
42924-53-8
Product Name Alternative
BRL 14777
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Ethanol: 25 mg/mL (109.5 mM) ; DMSO: 46 mg/mL (201.49 mM)
Smiles
CC (CCC1=CC=C2C=C (OC) C=CC2=C1) =O
Molecular Formula
C15H16O2
Molecular Weight
228.29
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4- (6-methoxynaphthalen-2-yl) butan-2-one

Alternative Products

CatalogName
B1450-SNabumetone

Popular Products