Nabumetone-d3

CAT: 0804-HY-B0559SSize: 1 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-B0559SSize:1 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

Nabumetone-d3 is the deuterium labeled Nabumetone. Nabumetone is an orally active non-acidic anti-inflammatory agent, acts as a potent and selective COX-2 inhibitor, and is the proagent of the active metabolite 6MNA.

CAS Number

1216770-08-9

Product Name Alternative

BRL14777-d3

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

COX; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Immunology/Inflammation; Others

Field of Research

Inflammation/Immunology; Cancer

Purity

98.80

Solubility

10 mM in DMSO

Smiles

CC(CCC1=CC2=C(C=C1)C=C(C=C2)OC([2H])([2H])[2H])=O

Molecular Formula

C15H13D3O2

Molecular Weight

231.30

Precautions

H315, H319, H320

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Vural F, et al. Cyclo-oxygenase 2 inhibitor, nabumetone, inhibits proliferation in chronic myeloid leukemia cell lines. Leuk Lymphoma. 2005 May;46 (5) :753-6.|[3]Melarange R, et al. Anti-inflammatory and gastrointestinal effects of nabumetone or its active metabolite, 6MNA (6-methoxy-2-naphthylacetic acid) : comparison with indomethacin. Agents Actions. 1992; Spec No:C82-3.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Chemical Information

Nabumetone-d3

CAS Number	1216770-08-9
PubChem CID	46782414
IUPAC Name	4-[6-(trideuteriomethoxy)naphthalen-2-yl]butan-2-one
Molecular Formula	C15H16O2
Molecular Weight	231.30
XLogP	3.1
Topological Polar Surface Area	26.3
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	4
Heavy Atom Count	17
Formal Charge	0
Complexity	262

SMILES

[2H]C([2H])([2H])OC1=CC2=C(C=C1)C=C(C=C2)CCC(=O)C

InChI

InChI=1S/C15H16O2/c1-11(16)3-4-12-5-6-14-10-15(17-2)8-7-13(14)9-12/h5-10H,3-4H2,1-2H3/i2D3

InChIKey

BLXXJMDCKKHMKV-BMSJAHLVSA-N

Chemical Structure

2D Structure

CAS: 1216770-08-9

CID: 46782414

Formula: C15H16O2

MW: 231.30

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	231.30
XLogP3	3.1
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	4
Exact Mass	231.133859987
Monoisotopic Mass	231.133859987
Topological Polar Surface Area	26.3 Å²
Heavy Atom Count	17
Formal Charge	0
Complexity	262
Isotope Atom Count	3
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
HY-B0559-01	Nabumetone
HY-B0559R-01	Nabumetone (Standard)
HY-15398S3-01	Vitamin D3-d3
HY-132348S1	Granisetron-d3 (1-methyl-d3)
HY-150954S	L-Methionine-d3 (S-methyl-d3) Methyl-d3-sulfonium Chloride
HY-W758392	(±) -Ipratropium-d3 Bromide (N-methyl-d3)
HY-B1213AS-01	Trimipramine-d3 (N-methyl-d3) (maleate)
HY-17373S2	Posaconazole-d3
HY-15345AS	Tetrahydrouridine-d3
HY-14771S	Imeglimin-d3

Alternative Products

Catalog	Name
TRC-N200502-5MG	Nabumetone-d3
B1450-S	Nabumetone

Nabumetone-d3

Chemical Information

Related Products

Alternative Products

Popular Products