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Lonidamine

CAT: 0013-GTR19161843-08Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19161843-08Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lonidamine is an orally administered small molecule hexokinase inactivator. (In Vitro) :Lonidamine (100 μM, 24 h) inhibits TGF-β-stimulated lactate production and oxygen consumption rate in AKR-2B and TIG-1 cells.Lonidamine (100 μM, 24/48 h) inhibits H2030BrM3 and A549 cell proliferation.Lonidamine (100-200 μM, 24 h) inhibits H2030BrM3 and A549 cell invasion.Lonidamine (100-1000 μM, 24 h) inhibits mitochondrial complex I and II activities.Lonidamine (200 μM, 24 h) increases ROS generation in H2030BrM3 lung cancer cells. (In Vivo) :Lonidamine (oral administration, 10-100 mg/kg/day, d10 to d20) improves lung function by inhibiting hexokinase 2 (HK2) activity in BLM-induced pulmonary fibrosis murine model.
CAS Number
50264-69-2
Product Name Alternative
AF 1890 | DICA | Diclondazolic Acid
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO: 64 mg/mL (199.27 mM)
Smiles
O=C (C1=NN (CC2=CC=C (Cl) C=C2Cl) C3=C1C=CC=C3) O
Molecular Formula
C15H10Cl2N2O2
Molecular Weight
321.17
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1- (2,4-dichlorobenzyl) -1H-indazole-3-carboxylic acid

Chemical Information

Lonidamine

Lonidamine is a member of the class of indazoles that is 1H-indazole that is substituted at positions 1 and 3 by 2,4-dichlorobenzyl and carboxy groups, respectively. It has a role as an antispermatogenic agent, a geroprotector, an antineoplastic agent and an EC 2.7.1.1 (hexokinase) inhibitor. It is a dichlorobenzene, a monocarboxylic acid and a member of indazoles.

CAS Number50264-69-2
PubChem CID39562
IUPAC Name1-[(2,4-dichlorophenyl)methyl]indazole-3-carboxylic acid
Molecular FormulaC15H10Cl2N2O2
Molecular Weight321.2
XLogP4.3
Topological Polar Surface Area55.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Heavy Atom Count21
Formal Charge0
Complexity396
SMILES
C1=CC=C2C(=C1)C(=NN2CC3=C(C=C(C=C3)Cl)Cl)C(=O)O
InChI
InChI=1S/C15H10Cl2N2O2/c16-10-6-5-9(12(17)7-10)8-19-13-4-2-1-3-11(13)14(18-19)15(20)21/h1-7H,8H2,(H,20,21)
InChIKey
WDRYRZXSPDWGEB-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Lonidamine
CAS: 50264-69-2
CID: 39562
Formula: C15H10Cl2N2O2
MW: 321.2
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight321.2
XLogP34.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass320.0119330
Monoisotopic Mass320.0119330
Topological Polar Surface Area55.1 Ų
Heavy Atom Count21
Formal Charge0
Complexity396
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
B1964-5Lonidamine

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