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Tubercidin

CAT: 0013-GTR19161742-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19161742-01Size:200 mg
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Description
An antibiotic and adenosine analog isolated from the bacterium Streptomyces tubercidicus with potential antineoplastic activity; incorporates into DNA and inhibits polymerases, thereby inhibiting DNA replication and RNA and protein synthesis; also exhibits antifungal and antiviral activities. (In Vitro) :Tubercidin (7-Deazaadenosine) (0-10 nM; 14 days) has a dose-dependent inhibitory effect on myeloid and erythroid human bone marrow progenitor cells, and the IC50s of tubercidin were 3.4 nM and 3.7 nM for CFU-GM and BFU-E, respectively. (In Vivo) :Tubercidin (7-Deazaadenosine) (intraperitoneal injection; 5 mg/kg; 10 days) in cooperation with NBMPR-P protects the mice from the lethality of tubercidin and allowed the repetition of the regimen for a second time with 100% survival.
CAS Number
69-33-0
Product Name Alternative
Sparsomycin A | 7-Deazaadenosine | NSC-56408
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 30 mg/mL
Smiles
NC1=NC=NC2=C1C=CN2[C@H]3[C@H] (O) [C@H] (O) [C@@H] (CO) O3
Molecular Formula
C11H14N4O4
Molecular Weight
266.2533
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-β-D-ribofuranosyl-

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