Trimethoprim

CAT: 0013-GTR19161609-02Size: 500 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19161609-02Size:500 mg

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Description

Trimethoprim is a Dihydrofolate Reductase Inhibitor Antibacterial. (In Vitro) :Trimethoprim interrupts folate metabolism by inhibition of the activity of dihydrofolase reductase (DHFR), which reduces dihydrofolate to tetrahydrofolate (THF) .Trimethoprim (3 μg/mL; 1 h) induces protein aggregation and main heat shock proteins (Hsps) in E. coli cells, which indicates that Trimethoprim sulfate presence leads to protein misfolding.Trimethoprim (1.5-3 μg/mL; 1 h) causes induction of DnaK, DnaJ, GroEL, ClpB, and IbpA/B Hsps in E. coli cells exposed to folate and heat stress. (In Vivo) :Trimethoprim (10 mg/kg; i.v.; once every 12 h; 3 d) shows antibacterial activity against H. influenzae, S. pneumoniae, E. coli and N. meningitidis in infected mice.Trimethoprim can be connected with the thiomaltose (TM-TMP) and shows stability with a half-life of about 1 hour in complete serum, and has an MIC value around 1 μM against E. coli.Trimethoprim (10 mg/mL; 0.5 mL; inject with Trimethoprim-Zn combined suspension) decreases the virus titer and increases the survival rate of chicken embryo.

CAS Number

738-70-5

Product Name Alternative

NIH 204 | NSC 106568

Field of Research

Pharmacology & Drug Discovery

Purity

>98% (HPLC)

Solubility

DMSO: 58 mg/mL (199.77 mM)

Smiles

NC1=NC=C (CC2=CC (OC) =C (OC) C (OC) =C2) C (N) =N1

Molecular Formula

C14H18N4O3

Molecular Weight

290.32

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

5- (3,4,5-Trimethoxybenzyl) pyrimidine-2,4-diamine

Chemical Information

Trimethoprim

Trimethoprim is an aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge. It has a role as a diuretic, a xenobiotic, an antibacterial drug, an EC 1.5.1.3 (dihydrofolate reductase) inhibitor, an environmental contaminant and a drug allergen. It is an aminopyrimidine and a member of methoxybenzenes.

CAS Number	738-70-5
PubChem CID	5578
IUPAC Name	5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine
Molecular Formula	C14H18N4O3
Molecular Weight	290.32
XLogP	0.9
Topological Polar Surface Area	106
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	5
Heavy Atom Count	21
Formal Charge	0
Complexity	307

SMILES

COC1=CC(=CC(=C1OC)OC)CC2=CN=C(N=C2N)N

InChI

InChI=1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)

InChIKey

IEDVJHCEMCRBQM-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 738-70-5

CID: 5578

Formula: C14H18N4O3

MW: 290.32

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	290.32
XLogP3	0.9
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	5
Exact Mass	290.13789045
Monoisotopic Mass	290.13789045
Topological Polar Surface Area	106 Å²
Heavy Atom Count	21
Formal Charge	0
Complexity	307
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
B2057-50	Trimethoprim

Trimethoprim

Chemical Information

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